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Literature summary for 2.3.1.43 extracted from

  • Rader, D.
    Lecithin: cholesterol acyltransferase and atherosclerosis: another high-density lipoprotein story that doesnt quite follow the script (2009), Circulation, 120, 549-552.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.43

Activating Compound

Activating Compound Comment Organism Structure
apolipoprotein A-I
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information loss-of-function LCAT mutants show highly decreased HDL-cholesteryl ester plasma levels and inability to form mature HDL particles, leading to progressive renal insufficiency, up to end-stage renal disease A, and corneal opacification, as well as to hemolytic anemia, phenotype of heterozygotes and homozygotes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + cholesterol Homo sapiens LCAT is critical in the metabolism of HDL cholesteryl ester + lysophosphatidylcholine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + cholesterol LCAT is critical in the metabolism of HDL Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?
phosphatidylcholine + cholesterol LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and subsequently transfers and esterifies the fatty acid to the beta3-hydroxyl group of free cholesterol using apolipoprotein A-I as cofactor Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?

Synonyms

Synonyms Comment Organism
LCAT
-
 Homo sapiens
lecithin: cholesterol acyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction native mutants show the fish-eye disease Homo sapiens
physiological function LCAT expression is inversely related to atherosclerosis, the enzyme is not atheroprotective Homo sapiens