Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ceramide | 30% activation, stimulation of synthesis of 20:4 cholesteryl ester and 18:2 cholesteryl ester, but not of 16:0 cholesteryl ester, a phosphocholine ether matrix abolishes the activation effect | Homo sapiens |
General Stability | Organism |
---|---|
the purified enzyme is instable | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ceramide phosphate | stronger physiologic inhibitory effect compared to sphingomyelin | Homo sapiens | |
additional information | no inhibition by ceramide | Homo sapiens | |
sphingomyelin | physiologic inhibitor, ceramide protects partially | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the activity and fatty acid specificity of LCAT may be altered during the inflammatory response | ? | - |
? | |
phosphatidylcholine + cholesterol | Homo sapiens | - |
1-acylglycerophosphocholine + cholesteryl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from plasma | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the activity and fatty acid specificity of LCAT may be altered during the inflammatory response | Homo sapiens | ? | - |
? | |
additional information | fatty acid specificity of LCAT, overview | Homo sapiens | ? | - |
? | |
phosphatidylcholine + cholesterol | - |
Homo sapiens | 1-acylglycerophosphocholine + cholesteryl ester | - |
? | |
phosphatidylcholine + cholesterol | proteoliposome substrates | Homo sapiens | 1-acylglycerophosphocholine + cholesteryl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCAT | - |
Homo sapiens |
lecithin-cholesterol acyltransferase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |