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Literature summary for 2.3.1.43 extracted from
- Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins (2005), Biochemistry, 44, 1013-1025.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| apolipoprotein A-I | activation level depends on the substrate, overview | Mus musculus | |
| apolipoprotein E | activation level depends on the substrate, overview | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of C-terminally His6-tagged LCAT in CHO cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mice deficient in apo A-I and especially in apoE lipoproteins show reduced plasma enzyme activity, overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Mus musculus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + cholesterol | Mus musculus | LCAT contributes significantly to the apoB lipoprotein cholesteryl ester pool, enzyme role in lipid and lipoprotein metabolism in plasma, detailed overview | 1-acylglycerophosphocholine + cholesteryl ester | - |
? |  |
| phosphatidylcholine + cholesterol | Mus musculus C57BL/6 | LCAT contributes significantly to the apoB lipoprotein cholesteryl ester pool, enzyme role in lipid and lipoprotein metabolism in plasma, detailed overview | 1-acylglycerophosphocholine + cholesteryl ester | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6 mice | - |
| Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + cholesterol | in presence of apoA-I lipoprotein | Mus musculus | 1-palmitoyl-sn-glycero-3-phosphocholine + cholesteryl oleate | - |
? | |
| 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + cholesterol | in presence of apoA-I lipoprotein | Mus musculus C57BL/6 | 1-palmitoyl-sn-glycero-3-phosphocholine + cholesteryl oleate | - |
? | |
| phosphatidylcholine + cholesterol | LCAT contributes significantly to the apoB lipoprotein cholesteryl ester pool, enzyme role in lipid and lipoprotein metabolism in plasma, detailed overview | Mus musculus | 1-acylglycerophosphocholine + cholesteryl ester | - |
? | |
| phosphatidylcholine + cholesterol | activity with apoB lipoprotein, overview | Mus musculus | 1-acylglycerophosphocholine + cholesteryl ester | - |
? | |
| phosphatidylcholine + cholesterol | LCAT contributes significantly to the apoB lipoprotein cholesteryl ester pool, enzyme role in lipid and lipoprotein metabolism in plasma, detailed overview | Mus musculus C57BL/6 | 1-acylglycerophosphocholine + cholesteryl ester | - |
? | |
| phosphatidylcholine + cholesterol | activity with apoB lipoprotein, overview | Mus musculus C57BL/6 | 1-acylglycerophosphocholine + cholesteryl ester | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LCAT | - |
Mus musculus |
| lecithin-cholesterol acyltransferase | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
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Release 2023.1 (January 2023)
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