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Literature summary for 2.3.1.43 extracted from

  • Hoang, A.; Huang, W.; Sasaki, J.; Sviridov, D.
    Natural mutations of apolipoprotein A-I impairing activation of lecithin:cholesterol acyltransferase (2003), Biochim. Biophys. Acta, 1631, 72-76.
    View publication on PubMed
Search for more literature for 2.3.1.43

Activating Compound

Activating Compound Comment Organism Structure
apolipoprotein A-I principal apolipoprotein of HDL, activates the enzyme, mutations of the activation site residues 110-160 of the apolipoprotein, responsible for activation, lead to loss of the activation activity, e.g. mutations A95D, Y100H, E110K, V156E, and H162Q of the protein Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics in presence of wild-type apolipoprotein A-I and different mutants of apolipoprotein A-I Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + cholesterol Homo sapiens the enzyme is responsible for esterification of cholesterol in high density lipoprotein HDL to prevent diffusion of cholesterol back to the cell 1-acylglycerophosphocholine + cholesteryl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the substrates are present in a ratio of 100:10:1 for phosphatidylcholine, cholesterol, and apolipoprotein A-I in the assay mixture Homo sapiens ?
-
 ?
phosphatidylcholine + cholesterol
-
 Homo sapiens 1-acylglycerophosphocholine + cholesteryl ester
-
 ?
phosphatidylcholine + cholesterol the enzyme is responsible for esterification of cholesterol in high density lipoprotein HDL to prevent diffusion of cholesterol back to the cell Homo sapiens 1-acylglycerophosphocholine + cholesteryl ester
-
 ?

Synonyms

Synonyms Comment Organism
lecithin:cholesterol acyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens