Literature summary for 2.3.1.43 extracted from

Lacko, A.G.; Reason, A.J.; Nuckolls, C.; Kudchodkar, B.J.; Nair, M.P.; Sundarrajan, G.; Pritchard, P.H.; Morris, H.R.; Dell, A.
Characterization of recombinant human plasma lecithin: cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties (1998), J. Lipid Res., 39, 807-820.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.14	-	1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine	phospholipase activity	Homo sapiens
0.19	-	1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine	phospholipase activity of recombinant enzyme expressed in baby hamster kidney cells	Homo sapiens
0.55	-	1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine	phospholipase activity of recombinant enzyme devoid of sialic acid, expressed in baby hamster kidney cells	Homo sapiens
7.44	-	1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine	-	Homo sapiens
10.1	-	1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine	recombinant enzyme expressed in baby hamster kidney cells	Homo sapiens
20.5	-	1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine	recombinant enzyme devoid of sialic acid, expressed in baby hamster kidney cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	glycans in recombinant enzyme, expressed in baby hamster kidney cells, have bi- and triantennary structures with or without core fucosylation	Homo sapiens
glycoprotein	glycans structure determined by mass spectrometry and linkage analysis	Homo sapiens

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine + cholesterol	-	Homo sapiens	cholesteryl-1-pyrenebutyrate + lysophosphatidylcholine	-	?
phosphatidylcholine + sterol	-	Homo sapiens	1-acylglycerophosphocholine + sterol ester	-	?

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Release 2023.1 (January 2023)