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Literature summary for 2.3.1.43 extracted from

  • Liu, M.; Subbaiah, P.V.
    Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferase (1994), Proc. Natl. Acad. Sci. USA, 91, 6035-6039.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.43

Cloned(Commentary)

Cloned (Comment) Organism
expression in baby hamster kidney cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diisopropyl fluorophosphate inhibits also the hydrolysis of platelet-activating factor by LCAT Homo sapiens
additional information serum albumin inhibits hydrolysis of platelet-activating factor by LCAT Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + sterol Homo sapiens
-
 1-acylglycerophosphocholine + sterol ester
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-alkyl-2-acetyl-sn-glycerol-3-phosphocholine + 1-O-acyl-2-lyso-sn-glycerol-3-phosphocholine
-
 Homo sapiens 1-O-alkyl-2-lyso-sn-glycerol-3-phosphocholine + 1-O-acyl-2-acetyl-sn-glycerol-3-phosphocholine
-
 ?
1-O-alkyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O hydrolysis of human platelet-activating factor PAF to lyso-PAF Homo sapiens 1-O-alkyl-2-lyso-sn-glycerol-3-phosphocholine + acetate
-
 ?
phosphatidylcholine + sterol
-
 Homo sapiens 1-acylglycerophosphocholine + sterol ester
-
 r

Cofactor

Cofactor Comment Organism Structure
additional information hydrolysis of platelet-activating factor by LCAT does not require apolipoprotein as cofactor Homo sapiens