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Literature summary for 2.3.1.43 extracted from
- A rapid large-scale procedure for purification of lecithin-cholesterol acyltransferase from human and animal plasma (1985), Biochim. Biophys. Acta, 834, 188-195.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| apolipoprotein A-I | - |
Homo sapiens | |
| apolipoprotein A-I | - |
Sus scrofa | |
| apolipoprotein A-I | - |
Oryctolagus cuniculus | |
| apolipoprotein A-I | - |
Canis lupus familiaris | |
| apolipoprotein A-I | - |
Capra hircus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| p-hydroxymercuribenzoate | - |
Canis lupus familiaris |  |
| p-hydroxymercuribenzoate | - |
Capra hircus | |
| p-hydroxymercuribenzoate | - |
Homo sapiens | |
| p-hydroxymercuribenzoate | - |
Oryctolagus cuniculus | |
| p-hydroxymercuribenzoate | - |
Sus scrofa | |
| phenylmethylsulfonyl fluoride | - |
Canis lupus familiaris | |
| phenylmethylsulfonyl fluoride | - |
Capra hircus | |
| phenylmethylsulfonyl fluoride | - |
Homo sapiens | |
| phenylmethylsulfonyl fluoride | - |
Oryctolagus cuniculus | |
| phenylmethylsulfonyl fluoride | - |
Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65000 | - |
x * 65000, SDS-PAGE | Homo sapiens |
| 65000 | - |
x * 65000, SDS-PAGE | Canis lupus familiaris |
| 65000 | - |
x * 65000, SDS-PAGE | Capra hircus |
| 66000 | - |
- |
Sus scrofa |
| 66000 | - |
HPLC gel filtration | Canis lupus familiaris |
| 66000 | - |
HPLC gel filtration | Capra hircus |
| 66000 | - |
x * 66000, SDS-PAGE | Oryctolagus cuniculus |
| 67000 | - |
HPLC gel filtration | Homo sapiens |
| 67000 | - |
HPLC gel filtration | Sus scrofa |
| 67000 | - |
HPLC gel filtration | Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
dog | - |
| Capra hircus | - |
goat | - |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
rabbit | - |
| Sus scrofa | - |
pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| precipitation from plasma with dextran sulfate-Mg2+ followed by several chromatographic steps, including DEAE-Sepharose, phenyl-Sepharose and affinity chromatography | Homo sapiens |
| precipitation from plasma with dextran sulfate-Mg2+ followed by several chromatographic steps, including DEAE-Sepharose, phenyl-Sepharose and affinity chromatography | Sus scrofa |
| precipitation from plasma with dextran sulfate-Mg2+ followed by several chromatographic steps, including DEAE-Sepharose, phenyl-Sepharose and affinity chromatography | Oryctolagus cuniculus |
| precipitation from plasma with dextran sulfate-Mg2+ followed by several chromatographic steps, including DEAE-Sepharose, phenyl-Sepharose and affinity chromatography | Canis lupus familiaris |
| precipitation from plasma with dextran sulfate-Mg2+ followed by several chromatographic steps, including DEAE-Sepharose, phenyl-Sepharose and affinity chromatography | Capra hircus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
| plasma | - |
Sus scrofa | - |
| plasma | - |
Oryctolagus cuniculus | - |
| plasma | - |
Canis lupus familiaris | - |
| plasma | - |
Capra hircus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.55 | - |
in cholesterol-lecithin vesicles activated with human apolipoprotein A1 | Capra hircus |
| 0.56 | - |
in cholesterol-lecithin vesicles activated with human apolipoprotein A1 | Oryctolagus cuniculus |
| 0.57 | - |
in cholesterol-lecithin vesicles activated with apolipoprotein A1 | Homo sapiens |
| 0.57 | - |
in cholesterol-lecithin vesicles activated with apolipoprotein A1 | Canis lupus familiaris |
| 0.59 | - |
in cholesterol-lecithin vesicles activated with human apolipoprotein A1 | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + sterol | - |
Homo sapiens | 1-acylglycerophosphocholine + sterol ester | - |
r | |
| phosphatidylcholine + sterol | - |
Sus scrofa | 1-acylglycerophosphocholine + sterol ester | - |
r | |
| phosphatidylcholine + sterol | - |
Oryctolagus cuniculus | 1-acylglycerophosphocholine + sterol ester | - |
r | |
| phosphatidylcholine + sterol | - |
Canis lupus familiaris | 1-acylglycerophosphocholine + sterol ester | - |
r | |
| phosphatidylcholine + sterol | - |
Capra hircus | 1-acylglycerophosphocholine + sterol ester | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 66000, SDS-PAGE | Sus scrofa |
| ? | x * 66000, SDS-PAGE | Oryctolagus cuniculus |
| ? | x * 65000, SDS-PAGE | Homo sapiens |
| ? | x * 65000, SDS-PAGE | Canis lupus familiaris |
| ? | x * 65000, SDS-PAGE | Capra hircus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
- |
Oryctolagus cuniculus |
| 7.6 | - |
- |
Canis lupus familiaris |
| 7.8 | - |
- |
Sus scrofa |
| 8 | - |
- |
Homo sapiens |
| 8 | - |
- |
Capra hircus |
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