Activating Compound | Comment | Organism | Structure |
---|---|---|---|
low-density lipoprotein | required for acylation of lysolecithin | Homo sapiens | |
Serum albumin | activates LCAT activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | heparin and serum albumin inhibit lysolecithin acyltransferase activity | Homo sapiens | |
Serum albumin | inhibits LAT activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
assay methods | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-acylglyceryl phosphorylcholine + lecithin | transfer of an acyl group from a lecithin molecule to another on the low-density lipoprotein surface, lysolecithin acyltransferase activity | Homo sapiens | lecithin + 1-acylglyceryl phosphorylcholine | - |
r | |
additional information | mechanism of LAT reaction is similar to that of LCAT, probably involving an acyl-enzyme intermediate, 2-acyl isomers of lysolecithin and lysophosphatidylethanolamine can act as substrates in the LAT reaction | Homo sapiens | ? | - |
? | |
phosphatidylcholine + sterol | - |
Homo sapiens | 1-acylglycerophosphocholine + sterol ester | - |
r |