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Literature summary for 2.3.1.42 extracted from
- Glycerolipid biosynthesis in Saccharomyces cerevisiae: sn-glycerol-3-phosphate and dihydroxyacetone phosphate acyltransferase activities (1978), J. Bacteriol., 133, 1368-1376.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | slight stimulation | Saccharomyces cerevisiae |  |
| Triton X-100 | 0.1 mg/ml | Saccharomyces cerevisiae | |
| Triton X-100 | inhibition above 0.1 mg/ml | Saccharomyces cerevisiae | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glycerol 3-phosphate | competitive to dihydroxyacetone phosphate | Saccharomyces cerevisiae | |
| N-ethylmaleimide | not peroxisomal enzyme | Saccharomyces cerevisiae | |
| Triton X-100 | 0.1 mg/ml; above 0.1 mg/ml | Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.79 | - |
dihydroxyacetone phosphate | - |
Saccharomyces cerevisiae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Saccharomyces cerevisiae | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| palmitoyl-CoA + dihydroxyacetone phosphate | Saccharomyces cerevisiae | initiates glycerolipid, especially ether-linked glycerolipid, biosynthesis in higher eukaryotes | CoA + monopalmitoyldihydroxyacetone phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
S288c | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + dihydroxyacetone phosphate | no acyl-donors are C4-C10-acyl-CoAs | Saccharomyces cerevisiae | CoA + acyldihydroxyacetone phosphate | i.e. acylglycerone phosphate | ? | |
| dodecanoyl-CoA + dihydroxyacetone phosphate | i.e. lauroyl-CoA, poor substrate | Saccharomyces cerevisiae | CoA + dodecanoyldihydroxyacetone phosphate | - |
? | |
| oleoyl-CoA + dihydroxyacetone phosphate | poor substrate | Saccharomyces cerevisiae | CoA + oleoyldihydroxyacetone phosphate | - |
? | |
| palmitoyl-CoA + dihydroxyacetone phosphate | - |
Saccharomyces cerevisiae | CoA + monopalmitoyldihydroxyacetone phosphate | - |
? | |
| palmitoyl-CoA + dihydroxyacetone phosphate | initiates glycerolipid, especially ether-linked glycerolipid, biosynthesis in higher eukaryotes | Saccharomyces cerevisiae | CoA + monopalmitoyldihydroxyacetone phosphate | - |
? | |
| stearoyl-CoA + dihydroxyacetone phosphate | - |
Saccharomyces cerevisiae | CoA + stearoyldihydroxyacetone phosphate | - |
? | |
| tetradecanoyl-CoA + dihydroxyacetone phosphate | i.e. myristoyl-CoA | Saccharomyces cerevisiae | CoA + tetradecanoyldihydroxyacetone phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 23 | - |
assay at | Saccharomyces cerevisiae |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 48 | - |
t1/2: 4 min | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Saccharomyces cerevisiae |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
about half-maximal activity above | Saccharomyces cerevisiae |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.07 | - |
glycerol 3-phosphate | - |
Saccharomyces cerevisiae | |
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