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Literature summary for 2.3.1.42 extracted from
- Does microsomal glycerophosphate acyltransferase also catalyze the acylation of dihydroxyacetone phosphate? (1984), FEBS Lett., 176, 264-268.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| deoxycholate | at low concentration | Rattus norvegicus |  |
| Triton X-100 | stimulation, up to 0.2 mg/ml | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| deoxycholate | weak, high concentration | Rattus norvegicus | |
| glycerol 3-phosphate | weak | Rattus norvegicus | |
| N-ethylmaleimide | no inhibition | Rattus norvegicus | |
| Triton X-100 | stimulation up to 0.2 mg/ml; weak | Rattus norvegicus | |
| Trypsin | not sensitive against | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Sprague-Dawley | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + dihydroxyacetone phosphate | - |
Rattus norvegicus | CoA + acyldihydroxyacetone phosphate | i.e. acylglycerone phosphate | ? | |
| acyl-CoA + dihydroxyacetone phosphate | - |
Rattus norvegicus Sprague-Dawley | CoA + acyldihydroxyacetone phosphate | i.e. acylglycerone phosphate | ? | |
| palmitoyl-CoA + dihydroxyacetone phosphate | - |
Rattus norvegicus | CoA + monopalmitoyldihydroxyacetone phosphate | - |
? | |
| palmitoyl-CoA + dihydroxyacetone phosphate | - |
Rattus norvegicus Sprague-Dawley | CoA + monopalmitoyldihydroxyacetone phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
membrane-bound: heat-stable | Rattus norvegicus |
| 50 | - |
intact microsomes: 25% loss of activity after 30 min | Rattus norvegicus |
| 55 | - |
15 min, stable | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 9.5 | about half-maximal activity at pH 5.5 and pH 9.5 | Rattus norvegicus |
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Release 2023.1 (January 2023)
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