Cloned (Comment) | Organism |
---|---|
expression as His-tagged protein in Escherichia coli | Haemophilus influenzae |
overexpression of His-tagged FabH in Escherichia coli BL21 (DE3) | Streptococcus pneumoniae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cerulenin | - |
Escherichia coli | |
cerulenin | - |
Haemophilus influenzae | |
cerulenin | - |
Streptococcus pneumoniae | |
SB418011 | - |
Escherichia coli | |
SB418011 | - |
Haemophilus influenzae | |
SB418011 | strong, synthase III | Streptococcus pneumoniae | |
thiolactomycin | synthase III | Escherichia coli | |
thiolactomycin | - |
Haemophilus influenzae | |
thiolactomycin | synthase III; weak | Streptococcus pneumoniae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0186 | - |
malonyl-[acyl-carrier protein] | synthase III | Streptococcus pneumoniae | |
0.0403 | - |
acetyl-CoA | synthase III | Streptococcus pneumoniae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
amino acid sequence alignment | Haemophilus influenzae |
additional information | - |
amino acid sequence alignment | Escherichia coli |
additional information | - |
amino acid sequence alignment | Streptococcus pneumoniae |
60000 | - |
synthase III, gel filtration | Streptococcus pneumoniae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Haemophilus influenzae | - |
- |
- |
Streptococcus pneumoniae | P0A3C5 | synthase III, gene fabH | - |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged protein from E. coli | Haemophilus influenzae |
recombinant His-tagged synthase III from E. coli | Streptococcus pneumoniae |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | synthaseIII/FabH: His-Asn-Cys catalytic triad | Haemophilus influenzae | |
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | synthaseIII/FabH: His-Asn-Cys catalytic triad | Escherichia coli | |
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | synthaseIII/FabH: His-Asn-Cys catalytic triad | Streptococcus pneumoniae |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.005 | - |
synthase III | Streptococcus pneumoniae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Haemophilus influenzae | acetoacyl-[acyl-carrier protein] + CO2 + CoA | - |
? | |
acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Escherichia coli | acetoacyl-[acyl-carrier protein] + CO2 + CoA | - |
? | |
acetyl-CoA + malonyl-[acyl-carrier protein] | synthase III, best substrate | Streptococcus pneumoniae | acetoacyl-[acyl-carrier protein] + CO2 + CoA | - |
? | |
additional information | - |
Escherichia coli | ? | - |
? | |
additional information | synthase III, FabH, has a preference for straight short-chain CoA primers | Streptococcus pneumoniae | ? | - |
? | |
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | substrate specificity, overview | Haemophilus influenzae | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | substrate specificity, overview | Escherichia coli | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | substrate specificity, overview | Streptococcus pneumoniae | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? |