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Literature summary for 2.3.1.41 extracted from

  • D'Agnolo, G.; Rosenfeld, I.S.; Vagelos, P.R.
    Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli (1975), J. Biol. Chem., 250, 5289-5294.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide acyl-[acyl-carrier-protein]-derivatives, e.g. acetyl-[acyl-carrier-protein], hexanoyl-CoA, octanoyl-CoA, decanoyl-CoA protect; synthase I and II Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
cis-3-decenoyl-[acyl-carrier protein] synthase I Escherichia coli
0.014
-
cis-3-decenoyl-[acyl-carrier protein] synthase II Escherichia coli
0.017
-
cis-9-hexadecenoyl-[acyl-carrier protein] synthase II Escherichia coli
0.031
-
acetyl-[acyl-carrier protein] synthase I Escherichia coli
0.04
-
acetyl-[acyl-carrier protein] synthase II Escherichia coli
0.138
-
cis-9-hexadecenoyl-[acyl-carrier protein] synthase I Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
synthase I, gel filtration Escherichia coli
76000
-
synthase II, gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] Escherichia coli part of non-associated fatty acid synthase system of plants and prokaryotes 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] Escherichia coli involved in biosynthesis of mono-unsaturated long-chain fatty acids 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
B
-
Escherichia coli
-
synthases I and II
-
Escherichia coli B / ATCC 11303
-
B
-

Purification (Commentary)

Purification (Comment) Organism
synthases I and II Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.5
-
purified synthase II Escherichia coli
9
-
purified synthase I Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Escherichia coli acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
r
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Escherichia coli B / ATCC 11303 acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
r
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] part of non-associated fatty acid synthase system of plants and prokaryotes Escherichia coli 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] involved in biosynthesis of mono-unsaturated long-chain fatty acids Escherichia coli 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
cis-3-decenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Escherichia coli 3-oxo-cis-5-dodecenoyl-[acyl-carrier protein] + acyl-carrier protein
-
?
cis-9-hexadecenoyl-CoA + malonyl-[acyl-carrier protein]
-
Escherichia coli 3-oxo-hexadecenoyl-[acyl-carrier protein] + CO2 + CoA
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] poor substrate, synthase I Escherichia coli 3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
r
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] best substrate, synthase II Escherichia coli 3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
r
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] poor substrate, synthase I Escherichia coli B / ATCC 11303 3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
r
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] from C-10 to C-16, e.g. cis-5-decenoyl-[acyl-carrier-protein], cis-5-dodecenoyl-[acyl-carrier-protein], cis-7-tetradecenoyl-[acyl-carrier-protein], cis-9-hexenoyl-[acyl-carrier-protein], i.e. palmitoleoyl-[acyl-carrier-protein], poor substrates Escherichia coli cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] from C-10 to C-16, e.g. cis-5-decenoyl-[acyl-carrier-protein], cis-5-dodecenoyl-[acyl-carrier-protein], cis-7-tetradecenoyl-[acyl-carrier-protein], cis-9-hexenoyl-[acyl-carrier-protein], i.e. palmitoleoyl-[acyl-carrier-protein], poor substrates Escherichia coli B / ATCC 11303 cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
additional information synthase I and II have nearly the same substrate specificity Escherichia coli ?
-
?
additional information synthase I and II have nearly the same substrate specificity Escherichia coli B / ATCC 11303 ?
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] substrate specificity, overview Escherichia coli 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
r
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] substrate specificity, overview Escherichia coli B / ATCC 11303 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
r

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
43
-
t1/2 synthase I: 18 min, t1/2 synthase II: 81 min Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5 6.1 synthase II Escherichia coli
7.2
-
synthase I Escherichia coli

pH Range

pH Minimum pH Maximum Comment Organism
5.2 7.6 synthase II, about half-maximal activity at pH 5.2 and pH 7.6 Escherichia coli
6.3 8 synthase I, about half-maximal activity at pH 6.3 and pH 8.0 Escherichia coli