Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | activation | Escherichia coli | |
dithiothreitol | activation | Escherichia coli | |
EDTA | activation | Escherichia coli |
Crystallization (Comment) | Organism |
---|---|
- |
Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetamide | no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation | Escherichia coli | |
N-ethylmaleimide | no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation | Clostridium kluyveri | |
N-ethylmaleimide | no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
2 * 35000, SDS-PAGE | Escherichia coli |
37000 | - |
2 * 37000, gel filtration after 6 M guanidinium chloride treatment | Escherichia coli |
66000 | - |
equilibrium centrifugation | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | Escherichia coli | part of non-associated fatty acid synthase system of plants and prokaryotes | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | Clostridium kluyveri | part of non-associated fatty acid synthase system of plants and prokaryotes | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | Escherichia coli | responsible for chain elongation during de novo fatty acid synthesis | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | Clostridium kluyveri | responsible for chain elongation during de novo fatty acid synthesis | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium kluyveri | - |
- |
- |
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | mechanism | Escherichia coli |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
14 | - |
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Escherichia coli | acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
acyl-CoA + [acyl-carrier protein] | catalyzes fatty acyl transfer between CoA and [acyl-carrier-protein], but no direct transfer to the enzyme as with acyl-[acyl-carrier-protein] | Escherichia coli | acyl-[acyl-carrier protein] + CoA | - |
? | |
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | part of non-associated fatty acid synthase system of plants and prokaryotes | Escherichia coli | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | part of non-associated fatty acid synthase system of plants and prokaryotes | Clostridium kluyveri | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | responsible for chain elongation during de novo fatty acid synthesis | Escherichia coli | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | responsible for chain elongation during de novo fatty acid synthesis | Clostridium kluyveri | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Escherichia coli | 3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Clostridium kluyveri | cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | not cis-vaccenoyl-[acyl-carrier-protein], i.e. cis-11-octenoyl-[acyl-carrier-protein] | Escherichia coli | cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Escherichia coli | dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Escherichia coli | 3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
malonyl-[acyl-carrier protein] | decarboxylation with 2-3% the rate of beta-ketoacyl-[acyl-carrier-protein]-synthesis | Escherichia coli | acetyl-[acyl-carrier protein] + CO2 | - |
? | |
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Clostridium kluyveri | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | substrate specificity, overview | Escherichia coli | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | not hexadecanoyl-[acyl-carrier-protein] | Escherichia coli | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | specific for acyl-[acyl-carrier-protein] thioesters, not acyl-CoA or acyl pantetheine thioesters | Escherichia coli | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Escherichia coli | 3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 35000, SDS-PAGE | Escherichia coli |
dimer | 2 * 37000, gel filtration after 6 M guanidinium chloride treatment | Escherichia coli |
More | vertebrates, yeast and Mycobacteria fatty acid synthetases contain all individual activities on one or two multifunctional polypeptide chains, plant, Escherichia coli and other prokaryotic fatty acid synthases are non-associated systems of individual enzymes | Escherichia coli |
More | vertebrates, yeast and Mycobacteria fatty acid synthetases contain all individual activities on one or two multifunctional polypeptide chains, plant, Escherichia coli and other prokaryotic fatty acid synthases are non-associated systems of individual enzymes | Clostridium kluyveri |
Synonyms | Comment | Organism |
---|---|---|
More | in vertebrates, yeast and Mycobacteria beta-ketoacyl synthase activity is a domain of the multifunctional polypeptide chains of fatty acid synthase EC 2.3.1.85 and EC 2.3.1.86 | Escherichia coli |
More | in vertebrates, yeast and Mycobacteria beta-ketoacyl synthase activity is a domain of the multifunctional polypeptide chains of fatty acid synthase EC 2.3.1.85 and EC 2.3.1.86 | Clostridium kluyveri |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 7.8 | - |
Escherichia coli |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 8 | - |
Escherichia coli |