Literature summary for 2.3.1.4 extracted from

Zhao, M.; Li, H.; Ma, Y.; Gong, H.; Yang, S.; Fang, Q.; Hu, Z.
Nanoparticle abraxane possesses impaired proliferation in A549 cells due to the underexpression of glucosamine 6-phosphate N-acetyltransferase 1 (GNPNAT1/GNA1) (2017), Int. J. Nanomedicine, 12, 1685-1697 .

No PubMed abstract available

Search for more literature for 2.3.1.4

Application

Application	Comment	Organism
medicine	analysis of the global protein expression profiles of lung cancer cell A549 treated with abraxane and paclitaxel. The superior drug effect of abraxane is mainly due to the downregulation of GNA1, which causes proliferative delay and cell adhesion defect	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96EK6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	treatment with abraxane results in downregulation of expression	down

General Information

General Information	Comment	Organism
physiological function	lack of GNA1 influences cell adhesion and restoration of its function rescues the biological defect	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)