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Literature summary for 2.3.1.37 extracted from

  • Varadharajan, S.; Dhanasekaran, S.; Bonday, Z.Q.; Rangarajan, P.N.; Padmanaban, G.
    Involvement of delta-aminolevulinate synthase encoded by the parasite gene in de novo heme synthesis by Plasmodium falciparum (2002), Biochem. J., 367, 321-327.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
pharmacology enzyme is a target for drug development because of its immunological and inhibitor specificity Plasmodium falciparum

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
aminomalonate weak Plasmodium falciparum
ethanolamine
-
Plasmodium falciparum
hemin inhibition of the import of the enzyme into the mitochondrial matrix Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
succinyl-CoA recombinant enzyme Plasmodium falciparum
50
-
glycine recombinant enzyme Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Plasmodium falciparum 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
63000
-
x * 63000, about, SDS-PAGE Plasmodium falciparum
158000
-
gel filtration Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinyl-CoA + glycine Plasmodium falciparum
-
5-aminolevulinate + CoA + CO2
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information import into mitochondria Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-CoA + glycine
-
Plasmodium falciparum 5-aminolevulinate + CoA + CO2
-
?

Subunits

Subunits Comment Organism
? x * 63000, about, SDS-PAGE Plasmodium falciparum