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Literature summary for 2.3.1.37 extracted from

  • Hofer, T.; Wenger, R.H.; Kramer, M.F.; Ferreira, G.C.; Gassmann, M.
    Hypoxic up-regulation of erythroid 5-aminolevulinate synthase (2003), Blood, 101, 348-350.
    View publication on PubMed
Search for more literature for 2.3.1.37

Activating Compound

Activating Compound Comment Organism Structure
additional information iron depletion does not increase isoform II promotor activity Mus musculus
O2 1%, 3fold increase in expression level, promotor activation in transiently transfected HeLa cells, hypoxia-inducible erythroid-isoform Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of erythroid-specific isoform and promotor-mutant in HeLa cells, luciferase reporter gene Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information site-directed mutagenesis of hypoxia-inducible factor-1, i.e. HIF-1, binding site in promotor sequence -328/-318, reveales HIF-1 like activation of enzyme expression during hypoxia Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinyl-CoA + glycine Mus musculus rate-limiting enzyme of heme biosynthesis 5-aminolevulinate + CoA + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 erythroid-specific isoform
-
Mus musculus
-
 gene ALAS-2
-
Mus musculus
-
 hypoxia-inducible
-

Source Tissue

Source Tissue Comment Organism Textmining
erythroleukemia cell line erythroid-specific isoform Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-CoA + glycine
-
 Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?
succinyl-CoA + glycine rate-limiting enzyme of heme biosynthesis Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus