Any feedback?
Literature summary for 2.3.1.37 extracted from
- Purification and properties of solubilized mitochondrial delta-aminolevulinic acid synthetase and comparison with the cytosol enzyme (1972), J. Biol. Chem., 247, 6818-6826.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hemin | - |
Cavia porcellus |  |
| hemin | feed-back inhibition | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | 0.01 | pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
| 0.2 | - |
succinyl-CoA | - |
Rattus norvegicus | |
| 19 | - |
glycine | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| mitochondrion | - |
Cavia porcellus | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| additional information | - |
Cavia porcellus | - |
- |
| additional information | processing of enzyme during to targeting to subcellular compartments | Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 77000 | - |
mitochondria, gel filtration | Rattus norvegicus |
| 178000 | - |
cytosol, gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
| Rattus norvegicus | - |
2 isoforms in cytosol and mitochondria | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cavia porcellus |
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Cavia porcellus | - |
| liver | porphyric | Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -15°C, loss of 25% activity within 10 days | Rattus norvegicus |
| 4°C, loss of 40% activity within 10 days | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-CoA + glycine | - |
Cavia porcellus | 5-aminolevulinate + CoA + CO2 | - |
? | |
| succinyl-CoA + glycine | - |
Rattus norvegicus | 5-aminolevulinate + CoA + CO2 | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Cavia porcellus | |
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
