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Literature summary for 2.3.1.32 extracted from

  • Naguleswaran, A.; Elias, E.; McClintick, J.; Edenberg, H.; Sullivan Jr., W.
    Toxoplasma gondii lysine acetyltransferase GCN5-a functions in the cellular response to alkaline stress and expression of cyst genes (2010), PLoS Pathog., 6, e1001232.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Toxoplasma gondii
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-
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Synonyms

Synonyms Comment Organism
GCN5-A
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 Toxoplasma gondii
lysine acetyltransferase
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 Toxoplasma gondii

Expression

Organism Comment Expression
Toxoplasma gondii an enrichment of TgGCN5-A at the upstream regions of genes activated by alkaline pH exposure is detected up

General Information

General Information Comment Organism
malfunction a TgGCN5-A null mutant is deficient in responding to alkaline pH, a common stress used to induce bradyzoite differentiation in vitro. A genome-wide analysis of the Toxoplasma transcriptional response to alkaline pH stress shows that parasites deleted for TgGCN5-A fail to up-regulate 74% of the stress response genes that are induced 2fold or more in wild-type. TgGCN5-A knockout is also incapable of up-regulating key marker genes expressed during development of the latent cyst form, and is impaired in its ability to recover from alkaline stress Toxoplasma gondii