Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.299 extracted from

  • Venkataraman, K.; Riebeling, C.; Bodennec, J.; Riezman, H.; Allegood, J.C.; Sullards, M.C.; Merrill, A.H.Jr.; Futerman, A.H.
    Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells (2002), J. Biol. Chem., 277, 35642-35649 .
    View publication on PubMed
Search for more literature for 2.3.1.299

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Mus musculus 5783
-
Golgi apparatus
-
 Mus musculus 5794
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 2 mM used in assay conditions Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
stearoyl-CoA + sphinganine Mus musculus
-
 N-(stearoyl)-sphinganine + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P27545
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with palmitoyl-CoA Mus musculus ?
-
-
stearoyl-CoA + sphinganine
-
 Mus musculus N-(stearoyl)-sphinganine + CoA
-
 ?

Synonyms

Synonyms Comment Organism
(dihydro)ceramide synthase
-
 Mus musculus
UOG1 gene name, upstream of growth and differentiation factor-1 Mus musculus

General Information

General Information Comment Organism
metabolism the N-(stearoyl)-sphinganine produced by the enzyme most significantly impacts neutral glycosphingolipid synthesis Mus musculus