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Literature summary for 2.3.1.299 extracted from

  • Turpin-Nolan, S.M.; Hammerschmidt, P.; Chen, W.; Jais, A.; Timper, K.; Awazawa, M.; Brodesser, S.; Bruening, J.C.
    CerS1-derived C18 0 ceramide in skeletal muscle promotes obesity-induced insulin resistance (2019), Cell Rep., 26, 1-10.e7 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
stearoyl-CoA + dihydroceramide Mus musculus
-
N-(stearoyl)-dihydroceramide + CoA
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
stearoyl-CoA + dihydroceramide
-
Mus musculus N-(stearoyl)-dihydroceramide + CoA
-
?

Synonyms

Synonyms Comment Organism
ceramide synthase 1
-
Mus musculus
CerS1
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus enzyme expression is increased in skeletal muscle of obese mice up

General Information

General Information Comment Organism
malfunction enzyme deletion, and the consequent reduction of C18:0 acyl-chain ceramide specifically in skeletal muscle, enhances whole-body glucose metabolism in obesity through increased muscle-derived circulating Fgf21 protein concentrations. Enzyme deficiency protects from insulin resistance Mus musculus