Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a molecular target for controlling resistance to photodynamic therapy | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + a sphingoid base | Homo sapiens | - |
an N-(stearoyl)-sphingoid base + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
head and neck squamous cell carcinoma cell | - |
Homo sapiens | - |
UM-SCC-22A cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + a sphingoid base | - |
Homo sapiens | an N-(stearoyl)-sphingoid base + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ceramide synthase 1 | - |
Homo sapiens |
CerS1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown leads to inhibition of photodynamic therapy-induced caspase 3-like activation, of apoptosis and cell death. Enzyme knockdown is associated with global and selective decreases in ceramides and dihydroceramides, in particular C18-, C18:1- and C20-ceramide post-photodynamic therapy | Homo sapiens |
physiological function | the enzyme regulates apoptotic resistance to photodynamic therapy for cancer treatment | Homo sapiens |