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Literature summary for 2.3.1.298 extracted from

  • Sassa, T.; Hirayama, T.; Kihara, A.
    Enzyme activities of the ceramide synthases CERS2-6 are regulated by phosphorylation in the C-terminal region (2016), J. Biol. Chem., 291, 7477-7487 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.298

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an ultra-long-chain fatty acyl-CoA + a sphingoid base Homo sapiens
-
 an ultra-long-chain ceramide + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation mildly increases the catalytic activity of the enzyme by 28% Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an ultra-long-chain fatty acyl-CoA + a sphingoid base
-
 Homo sapiens an ultra-long-chain ceramide + CoA
-
 ?
arachidoyl-CoA + sphingosine
-
 Homo sapiens arachidoyl ceramide + CoA
-
 ?
behenoyl-CoA + sphingosine
-
 Homo sapiens CoA + N-behenoylsphingosine
-
 ?
cerotoyl-CoA + sphingosine
-
 Homo sapiens cerotoyl ceramide + CoA
-
 ?
stearoyl-CoA + sphingosine
-
 Homo sapiens CoA + N-stearoylsphingosine
-
 ?

Synonyms

Synonyms Comment Organism
CerS3
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is essential for spermatogenesis and fertility Homo sapiens