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Literature summary for 2.3.1.298 extracted from

  • Rabionet, M.; Bayerle, A.; Jennemann, R.; Heid, H.; Fuchser, J.; Marsching, C.; Porubsky, S.; Bolenz, C.; Guillou, F.; Groene, H.J.; Gorgas, K.; Sandhoff, R.
    Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors (2015), Hum. Mol. Genet., 24, 4792-4808 .
    View publication on PubMed
Search for more literature for 2.3.1.298

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an ultra-long-chain fatty acyl-CoA + a sphingoid base Mus musculus
-
 an ultra-long-chain ceramide + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spermatid
-
 Mus musculus
-
spermatocyte
-
 Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an ultra-long-chain fatty acyl-CoA + a sphingoid base
-
 Mus musculus an ultra-long-chain ceramide + CoA
-
 ?
additional information the enzyme also accepts long or very long fatty acyl-CoAs as substrate Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ceramide synthase 3
-
 Mus musculus
CerS3
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme is upregulated first during meiosis and later on in mid-late spermiogenesis, in spermatocytes and in elongated spermatids up

General Information

General Information Comment Organism
malfunction enzyme loss leads to tubular atrophy and apoptosis of predominantly primary spermatocytes Mus musculus
physiological function the enzyme is quintessential for male fertility Mus musculus