Cloned (Comment) | Organism |
---|---|
expressed in HeLa cells | Mus musculus |
expressed in HeLa cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
an ultra-long-chain fatty acyl-CoA + a sphingoid base | Mus musculus | C26-C36 | an ultra-long-chain ceramide + CoA | - |
? | |
an ultra-long-chain fatty acyl-CoA + a sphingoid base | Homo sapiens | C26-C36 | an ultra-long-chain ceramide + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | - |
Mus musculus | - |
keratinocyte | - |
Homo sapiens | - |
skin | the enzyme localizes to upper stratum spinosum and stratum granulosum | Mus musculus | - |
skin | the enzyme localizes to upper stratum spinosum and stratum granulosum | Homo sapiens | - |
testis | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
an ultra-long-chain fatty acyl-CoA + a sphingoid base | C26-C36 | Mus musculus | an ultra-long-chain ceramide + CoA | - |
? | |
an ultra-long-chain fatty acyl-CoA + a sphingoid base | C26-C36 | Homo sapiens | an ultra-long-chain ceramide + CoA | - |
? | |
cerotoyl-CoA + sphingosine | - |
Mus musculus | cerotoyl ceramide + CoA | - |
? | |
cerotoyl-CoA + sphingosine | - |
Homo sapiens | cerotoyl ceramide + CoA | - |
? | |
lignoceroyl-CoA + sphingosine | - |
Mus musculus | lignoceroyl ceramide + CoA | - |
? | |
lignoceroyl-CoA + sphingosine | - |
Homo sapiens | lignoceroyl ceramide + CoA | - |
? | |
montanoyl-CoA + sphingosine | bona fide substrate | Mus musculus | montanoyl ceramide + CoA | - |
? | |
montanoyl-CoA + sphingosine | bona fide substrate | Homo sapiens | montanoyl ceramide + CoA | - |
? | |
additional information | the enzyme also uses long-chain and very-long-chain fatty acyl-CoAs as substrate | Mus musculus | ? | - |
? | |
additional information | the enzyme also uses long-chain and very-long-chain fatty acyl-CoAs as substrate | Homo sapiens | ? | - |
? | |
palmitoyl-CoA + sphingosine | - |
Mus musculus | CoA + N-palmitoylsphingosine | - |
? | |
palmitoyl-CoA + sphingosine | - |
Homo sapiens | CoA + N-palmitoylsphingosine | - |
? | |
stearoyl-CoA + sphingosine | - |
Mus musculus | CoA + N-stearoylsphingosine | - |
? | |
stearoyl-CoA + sphingosine | - |
Homo sapiens | CoA + N-stearoylsphingosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ceramide synthase 3 | - |
Mus musculus |
ceramide synthase 3 | - |
Homo sapiens |
CerS3 | - |
Mus musculus |
CerS3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deficiency in mice results in complete loss of ultra-long-chain acyl moities (C26 or higher), lack of continuous extracellular lipid lamellae and a non-functional cornified lipid envelope. Consequently newborn mutant mice die shortly after birth from transepidermal water loss. Mutant skin is also prone to Candida albicans infection | Mus musculus |