Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.297 extracted from

  • Kremser, C.; Klemm, A.L.; van Uelft, M.; Imgrund, S.; Ginkel, C.; Hartmann, D.; Willecke, K.
    Cell-type-specific expression pattern of ceramide synthase 2 protein in mouse tissues (2013), Histochem. Cell Biol., 140, 533-547.
    View publication on PubMed
Search for more literature for 2.3.1.297

Cloned(Commentary)

Cloned (Comment) Organism
gene cers2, expression analysis Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
 x * 42000, glycosylated enzyme, SDS-PAGE, x * 37000, deglycosylated enzyme, SDS-PAGE Mus musculus
42000
-
 x * 42000, glycosylated enzyme, SDS-PAGE, x * 37000, deglycosylated enzyme, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus ceramide synthase 2 catalyzes the synthesis of dihydroceramides from dihydrosphingosine and very long fatty acyl (C22-C24)-CoAs ?
-
 ?
additional information Mus musculus C57BL/6 ceramide synthase 2 catalyzes the synthesis of dihydroceramides from dihydrosphingosine and very long fatty acyl (C22-C24)-CoAs ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q924Z4 gene cers2
-
Mus musculus C57BL/6 Q924Z4 gene cers2
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain region- and development-dependent expression of the enzyme Mus musculus
-
choroid plexus epithelium
-
 Mus musculus
-
ependymal cell
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
lung
-
 Mus musculus
-
additional information cell-type-specific expression pattern of CerS2 protein, immunohistochemic analysis Mus musculus
-
neuron of cerebrum and cerebellum as well as in the white matter Mus musculus
-
oligodendrocyte
-
 Mus musculus
-
spleen
-
 Mus musculus
-
thymus
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000006 0.0000535 pH 7.4, 37°C, enzyme activity in mouse tissues, overview Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ceramide synthase 2 catalyzes the synthesis of dihydroceramides from dihydrosphingosine and very long fatty acyl (C22-C24)-CoAs Mus musculus ?
-
 ?
additional information ceramide synthase 2 catalyzes the synthesis of dihydroceramides from dihydrosphingosine and very long fatty acyl (C22-C24)-CoAs Mus musculus C57BL/6 ?
-
 ?
nervonoyl-CoA + NBD-sphinganine C24:1-CoA substrate and NBD-labeled sphinganine substrate, i.e. omega(7-nitro-2-1,3-benzoxadiazole-4-yl)(2S,3R)-2-aminooctadecane-1,3-diol Mus musculus CoA + N-nervonoyl-NBD-sphinganine
-
 ?
nervonoyl-CoA + NBD-sphinganine C24:1-CoA substrate and NBD-labeled sphinganine substrate, i.e. omega(7-nitro-2-1,3-benzoxadiazole-4-yl)(2S,3R)-2-aminooctadecane-1,3-diol Mus musculus C57BL/6 CoA + N-nervonoyl-NBD-sphinganine
-
 ?

Subunits

Subunits Comment Organism
? x * 42000, glycosylated enzyme, SDS-PAGE, x * 37000, deglycosylated enzyme, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
ceramide synthase 2
-
 Mus musculus
CerS2
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction CerS2-deficient (gene trap) mice exhibit myelin and behavioral abnormalities Mus musculus