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Literature summary for 2.3.1.291 extracted from
- Eleven residues determine the acyl chain specificity of ceramide synthases (2018), J. Biol. Chem., 293, 9912-9921 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in HEK-293T cell | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | a mutant based on the backbone of CerS5 (which generates C16-ceramide), containing an 11-residue sequence of a loop located between the last two putative transmembrane domainsfrom CerS2 (which generates C22-C24-ceramides), is altered such that it generates C22-C24 and other ceramides. The mutant generates C22:0-ceramide and C16:0-ceramide to a similar extent but also generates C18:0-, C20:0-, and C24:1-ceramides | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8N5B7 | isoform CerS5 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| palmitoyl-CoA + sphingosine | - |
Homo sapiens | CoA + N-palmitoylsphingosine | - |
? |  |
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Release 2023.1 (January 2023)
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