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Literature summary for 2.3.1.291 extracted from

  • Lahiri, S.; Futerman, A.H.
    LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor (2005), J. Biol. Chem., 280, 33735-33738 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
fumonisin B1
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D6K9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is higly selective toward palmitoyl-CoA as acyl donor Mus musculus ?
-
?
palmitoyl-CoA + a sphingoid base
-
Mus musculus an N-(palmitoyl)-sphingoid base + CoA
-
?
stearoyl-CoA + a sphingoid base about 10% of the activity with palmitoyl-CoA Mus musculus an N-(stearoyl)-sphingoid base + CoA
-
?

General Information

General Information Comment Organism
physiological function overexpression of LASS elevates the synthesis of (dihydro)ceramides selectively enriched in palmitic acid Mus musculus