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Literature summary for 2.3.1.291 extracted from

  • Jiang, Z.; Li, F.; Wan, Y.; Han, Z.; Yuan, W.; Cao, L.; Deng, Y.; Peng, X.; Chen, F.; Fan, X.; Liu, X.; Dai, G.; Wang, Y.; Zeng, Q.; Shi, Y.; Zhou, Z.; Chen, Y.; Xu, W.; Luo, S.; Chen, S.; Ye, X.; Mo, X.; Wu, X.; Li, Y.
    LASS5 interacts with SDHB and synergistically represses p53 and p21 activity (2016), Curr. Mol. Med., 16, 582-590 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N5B7
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function Lass5 interacts with succinate dehydrogenase subunit B. The C-terminal fragment of succinate dehydrogenase subunit B is required for the interaction. Lass5 and succinate dehydrogenase subunit B co-localize in COS-7 cells. Lass5 and succinate dehydrogenase subunit B expressions are up-regulated in neuroglioma tissue, and Lass5 or succinate dehydrogenase subunit B expression represses p53 or p21 reporter activity, respectively Homo sapiens