Literature summary for 2.3.1.289 extracted from

He, J.; Hertweck, C.
Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster (2003), Chem. Biol., 10, 1225-1232 .

No PubMed abstract available

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Organism

Organism	UniProt	Comment	Textmining
Streptomyces thioluteus	Q70KH8 and Q70KH5 and Q70KH4	Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC	-
Streptomyces thioluteus HKI-227	Q70KH8 and Q70KH5 and Q70KH4	Q70KH8 i.e. subunit AurA, Q70KH5 i.e. subunit AurB, Q70KH4 i.e. subunit AurC	-

General Information

General Information	Comment	Organism
physiological function	the aureothin biosynthetic gene cluster is composed of 4 modules and is encoded by three genes. The enzyme extends 4-nitrobenzoyl-CoA by 4 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA. The first module (encoded by aurA) is used twice in an iterative fashion, so that the five Claisen condensation reactions are catalysed by only four modules	Streptomyces thioluteus

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Release 2023.1 (January 2023)