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Literature summary for 2.3.1.286 extracted from

  • Landry, J.; Sutton, A.; Tafrov, S.T.; Heller, R.C.; Stebbins, J.; Pillus, L.; Sternglanz, R.
    The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases (2000), Proc. Natl. Acad. Sci. USA, 97, 5807-5811 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.286

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
nicotinamide
-
 Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His bind affinity resin column chromatography Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae [histone H3]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[histone H4]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae [histone H4]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
HST2
-
 Saccharomyces cerevisiae
NAD-dependent protein deacetylase
-
 Saccharomyces cerevisiae
silent information regulator 2
-
 Saccharomyces cerevisiae
Sir2
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Saccharomyces cerevisiae