Literature summary for 2.3.1.286 extracted from

Swygert, S.G.; Senapati, S.; Bolukbasi, M.F.; Wolfe, S.A.; Lindsay, S.; Peterson, C.L.
SIR proteins create compact heterochromatin fibers (2018), Proc. Natl. Acad. Sci. USA, 115, 12447-12452 .

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Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[histone H4]-N6-acetyl-L-lysine16 + NAD+ + H2O	overall reaction	Saccharomyces cerevisiae	[histone H4]-L-lysine16 + 2''-O-acetyl-ADP-D-ribose + nicotinamide	-	?

Synonyms

Synonyms	Comment	Organism
Sir2	-	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	heterochromatin assembly requires the SIR proteins Sir3, the primary structural component of SIR heterochromatin, and the Sir2-4 complex, responsible for the targeted recruitment of SIR proteins and the deacetylation of lysine 16 of histone H4	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)