Literature summary for 2.3.1.286 extracted from

Avalos, J.L.; Boeke, J.D.; Wolberger, C.
Structural basis for the mechanism and regulation of Sir2 enzymes (2004), Mol. Cell, 13, 639-648 .

Search for more literature for 2.3.1.286

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Archaeoglobus fulgidus

Crystallization (Commentary)

Crystallization (Comment)	Organism
enzyme in a productive complex with NAD+, in a nonproductive NAD+ complex and in the unliganded state, hanging drop vapor diffusion method, using 0.1 M HEPES (pH 7.4), 1.8 M ammonium sulfate, and 1% (w/v) PEG400 at 20°C	Archaeoglobus fulgidus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[protein]-N6-acetyl-L-lysine + NAD+ + H2O	Archaeoglobus fulgidus	-	[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide	-	?

Organism

Organism	UniProt	Comment	Textmining
Archaeoglobus fulgidus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Archaeoglobus fulgidus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[protein]-N6-acetyl-L-lysine + NAD+ + H2O	-	Archaeoglobus fulgidus	[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide	-	?

Synonyms

Synonyms	Comment	Organism
Sir2Af2	-	Archaeoglobus fulgidus

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Archaeoglobus fulgidus

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Release 2023.1 (January 2023)