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Literature summary for 2.3.1.286 extracted from

  • Khan, A.N.; Lewis, P.N.
    Unstructured conformations are a substrate requirement for the Sir2 family of NAD-dependent protein deacetylases (2005), J. Biol. Chem., 280, 36073-36078 .
    View publication on PubMed
Search for more literature for 2.3.1.286

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
acetyl-protamine
-
 Saccharomyces cerevisiae
poly-L-arginine
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Saccharomyces cerevisiae
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-cytochrome c + NAD+ + H2O the enzyme does not deacetylate native acetyl-cytochrome c but does deacetylate the heat-denatured substrate Saccharomyces cerevisiae ?
-
 ?
acetyl-poly-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
additional information the enzyme is specific for acetyl-lysine within proteins. It does not deacetylate small polycations such as acetyl-spermine or acetyl-protamine or acetylated amino termini of proteins. Furthermore, the enzyme displays conformational rather than sequence specificity, preferentially deacetylating acetyl-lysine within unstructured regions of proteins Saccharomyces cerevisiae ?
-
 ?
[histone H2B]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae [histone H2B]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[histone H2]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae [histone H2]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[histone H3]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae [histone H3]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[histone H4]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae [histone H4]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
HST2
-
 Saccharomyces cerevisiae
Sir2
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Saccharomyces cerevisiae