Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nicotinamide | - |
Archaeoglobus fulgidus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[protein]-N6-acetyl-L-lysine + NAD+ | Archaeoglobus fulgidus | - |
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide | - |
? | |
[protein]-N6-acetyl-L-lysine + NAD+ + H2O | Archaeoglobus fulgidus | overall reaction | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O | Archaeoglobus fulgidus | - |
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Archaeoglobus fulgidus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
HLKSKKGQSTSRHK(K-Ac)LMFK + NAD+ + H2O | p53A peptide | Archaeoglobus fulgidus | HLKSKKGQSTSRHKKLMFK + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
[protein]-N6-acetyl-L-lysine + NAD+ | - |
Archaeoglobus fulgidus | [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide | - |
? | |
[protein]-N6-acetyl-L-lysine + NAD+ + H2O | overall reaction | Archaeoglobus fulgidus | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O | - |
Archaeoglobus fulgidus | [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Af2Sir2 | - |
Archaeoglobus fulgidus |
Sir2 | - |
Archaeoglobus fulgidus |
sirtuin | - |
Archaeoglobus fulgidus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Archaeoglobus fulgidus |