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Literature summary for 2.3.1.286 extracted from

  • Hu, P.; Wang, S.; Zhang, Y.
    Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations (2008), J. Am. Chem. Soc., 130, 16721-16728 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.286

Protein Variants

Protein Variants Comment Organism
D101N the mutation affects the deacetylation activity of the enzyme Thermotoga maritima

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[protein]-N6-acetyl-L-lysine + NAD+ Thermotoga maritima
-
 [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ Thermotoga maritima ATCC 43589
-
 [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Thermotoga maritima overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Thermotoga maritima ATCC 43589 overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O Thermotoga maritima
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O Thermotoga maritima ATCC 43589
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Thermotoga maritima Q9WYW0
-
-
Thermotoga maritima ATCC 43589 Q9WYW0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[protein]-N6-acetyl-L-lysine + NAD+
-
 Thermotoga maritima [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+
-
 Thermotoga maritima ATCC 43589 [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Thermotoga maritima [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Thermotoga maritima ATCC 43589 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
-
 Thermotoga maritima [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
-
 Thermotoga maritima ATCC 43589 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?

Synonyms

Synonyms Comment Organism
silent information regulator 2
-
 Thermotoga maritima
Sir2
-
 Thermotoga maritima

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Thermotoga maritima