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Literature summary for 2.3.1.286 extracted from

  • Sauve, A.A.; Schramm, V.L.
    SIR2 the biochemical mechanism of NAD+-dependent protein deacetylation and ADP-ribosyl enzyme intermediates (2004), Curr. Med. Chem., 11, 807-826 .
    View publication on PubMed
Search for more literature for 2.3.1.286

Inhibitors

Inhibitors Comment Organism Structure
nicotinamide
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[protein]-N6-acetyl-L-lysine + NAD+ Saccharomyces cerevisiae
-
 [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Saccharomyces cerevisiae overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O Saccharomyces cerevisiae
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AGG(AcK)GG(AcK)GMG(AcK)VGA(AcK)RHSC + NAD+ + H2O tetraacetylated histone-H4 N-terminal tail peptide Saccharomyces cerevisiae AGG(AcK)GG(AcK)GMG(AcK)VGAKRHSC + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
ARTKQTAR(AcK)STGG(AcK)APRKQLC + NAD+ + H2O diacetyl ated histone-H3 N-terminal tail peptide Saccharomyces cerevisiae ARTKQTARKSTGGKAPRKQLC + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+
-
 Saccharomyces cerevisiae [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
-
 Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?

Synonyms

Synonyms Comment Organism
Sir2
-
 Saccharomyces cerevisiae
Sir2p
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function increase of enzyme activity by caloric restriction or osmotic stress increases genome stability and lifespan in Saccharomyces cerevisiae Saccharomyces cerevisiae