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Literature summary for 2.3.1.286 extracted from

  • Cattelan, A.; Ceolotto, G.; Bova, S.; Albiero, M.; Kuppusamy, M.; De Martin, S.; Semplicini, A.; Fadini, G.P.; de Kreutzenberg, S.V.; Avogaro, A.
    NAD+-dependent SIRT1 deactivation has a key role on ischemia-reperfusion-induced apoptosis (2015), Vascul. Pharmacol., 70, 35-44.
    View publication on PubMed
Search for more literature for 2.3.1.286

Activating Compound

Activating Compound Comment Organism Structure
resveratrol resveratrol restores SIRT1 activity and NAD+ level by an AMPK-dependent mechanism Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
sirtinol
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [Fluor de Lys protein]-N6-acyl-L-lysine Rattus norvegicus
-
 nicotinamide + [Fluor de Lys protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Rattus norvegicus
-
heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [Fluor de Lys protein]-N6-acyl-L-lysine
-
 Rattus norvegicus nicotinamide + [Fluor de Lys protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT1
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus ischemia-reperfusion induces a transient upregulation of isoform SIRT1 up

General Information

General Information Comment Organism
malfunction NAD+-dependent SIRT1 deactivation has a key role on ischemia-reperfusion-induced apoptosis Rattus norvegicus