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Literature summary for 2.3.1.286 extracted from

  • Tulino, R.; Benjamin, A.C.; Jolinon, N.; Smith, D.L.; Chini, E.N.; Carnemolla, A.; Bates, G.P.
    SIRT1 activity is linked to its brain region-specific phosphorylation and is impaired in Huntington's disease mice (2016), PLoS ONE, 11, e0145425.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.286

Activating Compound

Activating Compound Comment Organism Structure
AMP-activated protein kinase-alpha1 positive regulator of SIRT1 function Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q923E4
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
cerebellum
-
 Mus musculus
-
striatum
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [Fluor de Lys]-N6-acetyl-L-lysine
-
 Mus musculus nicotinamide + [Fluor de Lys]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Mus musculus

Expression

Organism Comment Expression
Mus musculus isoform SIRT1 activity is down-regulated in the brains of two complementary Huntington's disease mouse models down