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Literature summary for 2.3.1.286 extracted from

  • Lu, Z.; Chen, Y.; Aponte, A.M.; Battaglia, V.; Gucek, M.; Sack, M.N.
    Prolonged fasting identifies heat shock protein 10 as a sirtuin 3 substrate: elucidating a new mechanism linking mitochondrial protein acetylation to fatty acid oxidation enzyme folding and function (2015), J. Biol. Chem., 290, 2466-2476.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.286

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [heat shock protein 10]-N6-acetyl-L-lysine56 Mus musculus
-
 nicotinamide + [heat shock protein 10]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8R104
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [heat shock protein 10]-N6-acetyl-L-lysine56
-
 Mus musculus nicotinamide + [heat shock protein 10]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT3
-
 Mus musculus
sirtuin 3
-
 Mus musculus

General Information

General Information Comment Organism
metabolism isoform SIRT3 levels modulate mitochondrial protein folding Mus musculus
physiological function acetylation of heat shock protein 10 by isoform SIRT3 enhances medium-chain acyl-CoA dehydrogenase folding, enzyme activity, and fat oxidation Mus musculus