Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382 | Homo sapiens | - |
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose | - |
? | |
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382 | Rattus norvegicus | - |
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96EB6 | - |
- |
Rattus norvegicus | Q96EB6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
visceral fat | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382 | - |
Homo sapiens | nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose | - |
? | |
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382 | - |
Rattus norvegicus | nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SIRT1 | - |
Homo sapiens |
SIRT1 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression of SIRT1 is induced in human cells that are treated with human serum. Insulin and insulin-like growth factor 1 (IGF-1) attenuate this response | up |
Rattus norvegicus | expression of SIRT1 is induced in rat cells that are treated with rat serum. Insulin and insulin-like growth factor 1 (IGF-1) attenuate this response | up |
Rattus norvegicus | tissues are extracted from 12-month-old rats that had either been fed ad libitum (AL) or a caloric restriction diet (CR, 60% of AL) since weaning. Compared to expression in AL animals, SIRT1 expression is higher in many tissues of the CR animals, including brain, visceral fat pads, kidney, and liver | up |
General Information | Comment | Organism |
---|---|---|
metabolism | caloric restriction can extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells | Homo sapiens |
metabolism | caloric restriction can extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells | Rattus norvegicus |