Literature summary for 2.3.1.286 extracted from

Li, X.; Zhang, S.; Blander, G.; Tse, J.G.; Krieger, M.; Guarente, L.
SIRT1 deacetylates and positively regulates the nuclear receptor LXR (2007), Mol. Cell., 28, 91-106.

Search for more literature for 2.3.1.286

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [nuclear receptor LXR]-N6-acetyl-L-lysine	Homo sapiens	SIRT1 positively regulates liver X receptors (LXRs) by deacetylation at lysine. Deacetylation of liver X receptors (LXRs) by SIRT1 may be a mechanism that affects atherosclerosis and other agingassociated diseases	nicotinamide + [nuclear receptor LXR]-L-lysine + 2'-O-acetyl-ADP ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96EB6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [nuclear receptor LXRalpha]-N6-acetyl-L-lysine432	-	Homo sapiens	nicotinamide + [nuclear receptor LXRalpha]-L-lysine432 + 2'-O-acetyl-ADP ribose	-	?
NAD+ + [nuclear receptor LXRbeta]-N6-acetyl-L-lysine433	-	Homo sapiens	nicotinamide + [nuclear receptor LXRbeta]-L-lysine433 + 2'-O-acetyl-ADP ribose	-	?
NAD+ + [nuclear receptor LXR]-N6-acetyl-L-lysine	SIRT1 positively regulates liver X receptors (LXRs) by deacetylation at lysine. Deacetylation of liver X receptors (LXRs) by SIRT1 may be a mechanism that affects atherosclerosis and other agingassociated diseases	Homo sapiens	nicotinamide + [nuclear receptor LXR]-L-lysine + 2'-O-acetyl-ADP ribose	-	?

Synonyms

Synonyms	Comment	Organism
SIRT1	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)