additional information
no activity with the crotonylated histone H3 peptide QTAR(N6-crotonyl)KSTGG
730024
Homo sapiens
?
?
additional information
no activity with the succinylated histone H3 peptide QTAR(N6-succinyl)KSTGG
730024
Homo sapiens
?
?
NAD+ + QTAR(N6-acetyl)KSTGG
acetylated histone H3 peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-acetyl-ADP-ribose
?
NAD+ + QTAR(N6-butyryl)KSTGG
butyrylated histone H3 peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
?
NAD+ + QTAR(N6-butyryl)KSTGG
butyrylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
?
NAD+ + QTAR(N6-butyryl)KSTGG
butyrylated histone H3 peptide, about 5% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
?
NAD+ + QTAR(N6-crotonyl)KSTGG
crotonylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose
?
NAD+ + QTAR(N6-crotonyl)KSTGG
crotonylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose
?
NAD+ + QTAR(N6-decanoyl)KSTGG
decanoylated histone H3 peptide, about 50% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
?
NAD+ + QTAR(N6-decanoyl)KSTGG
decanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
?
NAD+ + QTAR(N6-decanoyl)KSTGG
decanoylated histone H3 peptide, about 80% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
?
NAD+ + QTAR(N6-decanoyl)KSTGG
myristoylated histone H3 peptide, about 50% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
?
NAD+ + QTAR(N6-decanoyl)KSTGG
myristoylated histone H3 peptide, about 65% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
dodecanoylated histone H3 peptide, about 30% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
dodecanoylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
dodecanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
hexanoylated histone H3 peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
hexanoylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
hexanoylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
?
NAD+ + QTAR(N6-myristoyl)KSTGG
myristoylated histone H3 peptide, about 45% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-myristoyl-ADP-ribose
?
NAD+ + QTAR(N6-octanoyl)KSTGG
octanoylated histone H3 peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
?
NAD+ + QTAR(N6-octanoyl)KSTGG
octanoylated histone H3 peptide, about 35% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
?
NAD+ + QTAR(N6-octanoyl)KSTGG
octanoylated histone H3 peptide, about 55% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
?
NAD+ + QTAR(N6-palmitoyl)KSTGG
myristoylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-palmitoyl-ADP-ribose
?
NAD+ + QTAR(N6-propionyl)KSTGG
propionylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
?
NAD+ + QTAR(N6-propionyl)KSTGG
propionylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
?
NAD+ + QTAR(N6-propionyl)KSTGG
propionylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
?
NAD+ + QTAR(N6-succinyl)KSTGG
succinylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-succinyl-ADP-ribose
?
NAD+ + [protein]-N6-succinyl-L-lysine
730024
Homo sapiens
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
?
additional information
no activity with the crotonylated histone H3 peptide QTAR(N6-crotonyl)KSTGG
730024
Homo sapiens
?
?
additional information
no activity with the succinylated histone H3 peptide QTAR(N6-succinyl)KSTGG
730024
Homo sapiens
?
?
NAD+ + QTAR(N6-acetyl)KSTGG
acetylated histone H3 peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-acetyl-ADP-ribose
?
NAD+ + QTAR(N6-butyryl)KSTGG
butyrylated histone H3 peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
?
NAD+ + QTAR(N6-butyryl)KSTGG
butyrylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
?
NAD+ + QTAR(N6-butyryl)KSTGG
butyrylated histone H3 peptide, about 5% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
?
NAD+ + QTAR(N6-crotonyl)KSTGG
crotonylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose
?
NAD+ + QTAR(N6-crotonyl)KSTGG
crotonylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose
?
NAD+ + QTAR(N6-decanoyl)KSTGG
decanoylated histone H3 peptide, about 50% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
?
NAD+ + QTAR(N6-decanoyl)KSTGG
decanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
?
NAD+ + QTAR(N6-decanoyl)KSTGG
decanoylated histone H3 peptide, about 80% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
?
NAD+ + QTAR(N6-decanoyl)KSTGG
myristoylated histone H3 peptide, about 50% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
?
NAD+ + QTAR(N6-decanoyl)KSTGG
myristoylated histone H3 peptide, about 65% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
dodecanoylated histone H3 peptide, about 30% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
dodecanoylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
dodecanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
hexanoylated histone H3 peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
hexanoylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
hexanoylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
?
NAD+ + QTAR(N6-myristoyl)KSTGG
myristoylated histone H3 peptide, about 45% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-myristoyl-ADP-ribose
?
NAD+ + QTAR(N6-octanoyl)KSTGG
octanoylated histone H3 peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
?
NAD+ + QTAR(N6-octanoyl)KSTGG
octanoylated histone H3 peptide, about 35% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
?
NAD+ + QTAR(N6-octanoyl)KSTGG
octanoylated histone H3 peptide, about 55% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
?
NAD+ + QTAR(N6-palmitoyl)KSTGG
myristoylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-palmitoyl-ADP-ribose
?
NAD+ + QTAR(N6-propionyl)KSTGG
propionylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
?
NAD+ + QTAR(N6-propionyl)KSTGG
propionylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
?
NAD+ + QTAR(N6-propionyl)KSTGG
propionylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
?
NAD+ + QTAR(N6-succinyl)KSTGG
succinylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide
730024
Homo sapiens
nicotinamide + QTARKSTGG + 2'-O-succinyl-ADP-ribose
?
NAD+ + [protein]-N6-succinyl-L-lysine
730024
Homo sapiens
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
?
752056
Swygert
SIR proteins create compact h ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
115
12447-12452
2018
-
-
-
-
-
-
-
-
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-
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-
1
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1
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1
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1
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1
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1
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-
-
-
-
-
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1
1
-
-
-
757557
Christensen
Identification of novel prote ...
Escherichia coli
mBio
9
e01905-18
2018
-
-
4
-
7
-
-
-
-
-
-
8
-
4
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11
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21
-
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4
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4
4
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7
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8
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11
-
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-
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-
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-
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12
12
-
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749818
Anand
A Sir2 family protein Rv1151c ...
Mycobacterium tuberculosis
Biochem. Biophys. Res. Commun.
493
1204-1209
2017
-
-
1
-
-
-
-
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1
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6
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1
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1
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2
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1
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1
1
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1
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1
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-
1
-
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-
-
-
-
-
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-
-
-
-
-
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751295
Kang
HST1 increases replicative li ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
J. Microbiol.
55
123-129
2017
-
-
-
-
-
-
-
-
-
-
-
2
-
73
-
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-
-
-
-
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4
-
3
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1
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1
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2
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-
-
4
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
737969
Bhalla
Functional characterization of ...
Homo sapiens
Cancer Biol. Ther.
17
300-309
2016
-
-
-
-
-
-
2
-
-
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1
-
3
-
-
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-
-
4
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1
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1
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1
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1
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2
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1
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4
-
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1
-
-
-
-
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-
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1
1
1
1
-
-
738942
Song
Deacetylation assays to unrave ...
Homo sapiens
J. Vis. Exp.
108
53563
2016
-
-
-
-
-
-
-
-
1
-
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1
-
1
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-
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-
-
-
-
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1
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1
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-
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-
-
1
-
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1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739439
Tulino
SIRT1 activity is linked to it ...
Mus musculus
PLoS ONE
11
e0145425
2016
1
-
-
-
-
-
-
-
-
-
-
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5
-
1
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-
-
4
-
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1
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1
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-
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-
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1
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1
-
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1
-
-
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1
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4
-
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1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
739686
Aragones
Dietary proanthocyanidins boos ...
Rattus norvegicus
Sci. Rep.
6
24977
2016
-
-
-
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-
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-
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1
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3
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2
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2
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2
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1
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2
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2
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-
-
-
-
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1
1
1
1
-
-
729603
Di Fruscia
The discovery of a highly sele ...
Homo sapiens
ChemMedChem
10
69-82
2015
-
1
1
-
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7
-
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1
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1
-
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1
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1
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1
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1
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7
-
1
1
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7
7
1
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1
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1
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1
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737389
Rumpf
Seeding for sirtuins: microsee ...
Homo sapiens
Acta Crystallogr. Sect. F
71
1498-1510
2015
-
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2
2
-
-
-
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2
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2
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5
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2
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-
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2
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2
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-
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2
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2
2
2
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2
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2
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2
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-
-
2
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738108
Yang
SIRT3-dependent GOT2 acetylati ...
Homo sapiens
EMBO J.
34
1110-1125
2015
-
-
-
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1
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1
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3
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1
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1
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1
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1
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1
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1
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1
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1
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1
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738438
Lee
Sirtuin 1 (SIRT1) deacetylase ...
Homo sapiens
J. Agric. Food Chem.
63
7361-7370
2015
-
-
-
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1
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2
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4
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1
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1
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4
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1
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1
1
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738661
Lu
Prolonged fasting identifies h ...
Mus musculus
J. Biol. Chem.
290
2466-2476
2015
-
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1
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1
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1
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1
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1
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1
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1
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1
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2
2
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-
-
738674
Weiser
Propofol inhibits SIRT2 deacet ...
Rattus norvegicus, Homo sapiens
J. Biol. Chem.
290
8559-8568
2015
-
-
-
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-
-
13
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2
2
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6
-
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1
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2
2
2
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13
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2
2
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1
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739214
Fang
Enhancement of NAD+-dependent ...
Rattus norvegicus, Homo sapiens
Oncotarget
6
42879-42891
2015
-
-
-
-
-
-
6
-
-
-
-
2
-
5
-
-
-
-
-
3
-
-
2
-
2
-
-
-
-
-
-
-
2
-
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-
-
-
2
-
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-
-
6
-
-
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-
2
-
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-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739412
Zhang
SIRT3 and SIRT5 regulate the e ...
Mus musculus
PLoS ONE
10
e0122297
2015
-
-
-
-
1
-
-
-
-
-
-
1
-
5
-
-
-
-
-
1
-
-
1
-
2
-
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-
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1
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739668
Teng
Efficient demyristoylase activ ...
Homo sapiens
Sci. Rep.
5
8529
2015
-
-
1
1
-
-
-
2
-
-
-
2
-
1
-
-
1
-
-
-
-
-
9
-
1
-
-
-
2
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
2
-
-
-
2
-
-
-
1
-
-
-
-
9
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
739727
Pasha
-
Amberlyst-15 catalyzed Povarov ...
Homo sapiens
Tetrahedron Lett.
56
2289-2292
2015
-
-
-
-
-
-
6
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739745
Cattelan
NAD+-dependent SIRT1 deactivat ...
Rattus norvegicus
Vascul. Pharmacol.
70
35-44
2015
1
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
729498
Wang
Down-regulation of sirtuin 3 i ...
Homo sapiens
BMC Cancer
14
297
2014
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
729674
Khanfar
Development and characterizati ...
Homo sapiens
Eur. J. Med. Chem.
76
414-426
2014
-
1
-
-
-
-
24
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
24
-
1
-
-
-
-
-
24
24
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
729680
Kokkonen
Quantitative insights for the ...
Homo sapiens
Eur. J. Pharm. Sci.
59
12-19
2014
-
1
-
-
-
-
13
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
730474
Lutz
Distinct patterns of sirtuin e ...
Homo sapiens
Neuromolecular Med.
16
405-414
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
730679
Guan
Mechanism of inhibition of the ...
Homo sapiens
PLoS One
15
e107729
2014
-
-
-
-
-
-
2
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
4
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
730980
Yamagata
Structural basis for potent in ...
Homo sapiens
Structure
22
345-352
2014
-
-
-
1
-
-
1
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
729164
Madabushi
Histone deacetylase SIRT1 modu ...
Homo sapiens
Biochem. J.
456
89-98
2013
-
-
1
-
-
-
-
-
-
-
-
1
-
5
-
-
1
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
730024
Feldman
Activation of the protein deac ...
Homo sapiens
J. Biol. Chem.
288
31350-31356
2013
-
-
-
-
-
-
-
-
-
-
-
3
-
3
-
-
-
1
-
-
-
-
34
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
34
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
730166
Zhao
The 2.5 A crystal structure of ...
Homo sapiens
J. Med. Chem.
56
963-969
2013
-
-
1
1
-
-
1
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
730287
Moniot
Crystal structure analysis of ...
Homo sapiens
J. Struct. Biol.
182
136-143
2013
-
-
1
1
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
749528
Whitaker
Increased expression of Droso ...
Drosophila melanogaster
Aging
5
682-691
2013
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
750413
Buscaino
Distinct roles for Sir2 and R ...
Schizosaccharomyces pombe
EMBO J.
32
1250-1264
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
728857
Maurer
Inhibitors of the NAD(+)-depen ...
Homo sapiens
ACS Med. Chem. Lett.
3
1050-1053
2012
-
-
-
-
-
-
22
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
-
-
32
-
-
-
-
-
-
-
32
64
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
729982
Yu
SIRT3 protein deacetylates iso ...
Mus musculus
J. Biol. Chem.
287
14078-14086
2012
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
730706
Fischer
Sirt5 deacylation activities s ...
Homo sapiens
PLoS One
7
e45098
2012
-
-
1
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
1
1
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
730713
Gertz
A molecular mechanism for dire ...
Homo sapiens
PLoS One
7
e49761
2012
-
-
1
1
-
-
2
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
730947
Guo
The NAD(+)-dependent protein d ...
Mus musculus
Sci. Rep.
2
640
2012
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
749470
Zhu
Plasmodium falciparum Sir2A p ...
Plasmodium falciparum
ACS Chem. Biol.
7
155-159
2012
-
-
1
1
-
-
-
4
-
-
-
-
-
4
-
-
1
-
-
-
-
-
5
-
2
-
-
-
4
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
4
-
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
4
-
-
-
-
-
1
1
-
4
4
750907
Dancy
Azalysine analogues as probes ...
Thermotoga maritima
J. Am. Chem. Soc.
134
5138-5148
2012
-
-
1
-
-
-
-
2
-
-
-
3
-
1
-
-
1
-
-
-
-
-
5
-
1
-
-
-
2
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
2
-
-
-
3
-
-
-
1
-
-
-
-
5
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
718508
Holbourn
Cloning, purification, crystal ...
Homo sapiens
Acta Crystallogr. Sect. F
67
461-463
2011
-
-
1
1
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
730103
Geng
SIRT1 and SIRT5 activity expre ...
Rattus norvegicus
J. Cell. Biochem.
112
3755-3761
2011
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
729970
Ponugoti
SIRT1 deacetylates and inhibit ...
Mus musculus
J. Biol. Chem.
285
33959-33970
2010
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
750905
Cen
Transition state of ADP-ribos ...
Archaeoglobus fulgidus
J. Am. Chem. Soc.
132
12286-12298
2010
-
-
-
-
-
-
1
-
-
-
-
3
-
5
-
-
-
-
-
-
-
-
4
-
3
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
729561
Asher
SIRT1 regulates circadian cloc ...
Homo sapiens
Cell
134
317-328
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
730205
Schlicker
Substrates and regulation mech ...
Homo sapiens
J. Mol. Biol.
382
790-801
2008
-
-
1
-
-
-
-
-
2
-
-
2
-
4
-
-
1
-
-
-
-
-
5
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
749886
French
Plasmodium falciparum Sir2 is ...
Plasmodium falciparum
Biochemistry
47
10227-10239
2008
-
-
1
-
-
-
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3
-
-
-
-
-
3
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-
-
-
-
-
-
-
-
-
750904
Hu
Highly dissociative and conce ...
Thermotoga maritima, Thermotoga maritima ATCC 43589
J. Am. Chem. Soc.
130
16721-16728
2008
-
-
-
-
1
-
-
-
-
-
-
6
-
2
-
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6
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-
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-
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-
729683
Jeong
SIRT1 promotes DNA repair acti ...
Homo sapiens
Exp. Mol. Med.
39
8-13
2007
-
-
-
-
-
-
-
-
-
-
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1
-
3
-
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2
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-
-
1
1
-
-
-
730388
Li
SIRT1 deacetylates and positiv ...
Homo sapiens
Mol. Cell.
28
91-106
2007
-
-
-
-
-
-
-
-
-
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1
-
2
-
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-
-
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3
-
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-
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-
749884
Smith
Mechanism-based inhibition of ...
Saccharomyces cerevisiae, Homo sapiens
Biochemistry
46
14478-14486
2007
-
-
-
-
-
-
8
-
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-
-
2
-
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6
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-
-
-
751549
Sanders
Structural basis for nicotina ...
Saccharomyces cerevisiae
Mol. Cell
25
463-472
2007
-
-
-
1
9
-
1
4
-
-
-
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1
-
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-
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-
-
-
-
-
-
729802
Vaquero
SirT2 is a histone deacetylase ...
Homo sapiens
Genes Dev.
20
1256-1261
2006
-
-
-
-
-
-
-
-
2
-
-
1
-
5
-
-
1
-
-
-
-
-
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4
-
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-
-
-
-
-
1
1
-
-
-
749880
Smith
Sir2 protein deacetylases ev ...
Saccharomyces cerevisiae
Biochemistry
45
272-282
2006
-
-
-
-
1
-
-
-
-
-
-
3
-
1
-
-
-
-
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5
-
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-
-
-
-
-
-
2
2
751016
Marsh
Sir2 and the acetyltransferas ...
Saccharolobus solfataricus, Saccharolobus solfataricus P2
J. Biol. Chem.
280
21122-21128
2005
-
-
-
-
-
-
-
-
-
-
-
2
-
41
-
-
-
-
-
-
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2
-
1
-
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-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
751017
Khan
Unstructured conformations ar ...
Saccharomyces cerevisiae
J. Biol. Chem.
280
36073-36078
2005
-
-
1
-
-
-
2
-
-
-
-
1
-
1
-
-
-
-
-
-
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8
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-
-
8
-
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-
-
-
-
-
-
-
-
-
-
-
-
730962
Cohen
Calorie restriction promotes m ...
Homo sapiens, Rattus norvegicus
Science
305
390-392
2004
-
-
-
-
-
-
-
-
-
-
-
2
-
6
-
-
-
-
-
4
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4
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2
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-
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-
3
2
2
3
-
-
750369
Sauve
SIR2 the biochemical mechani ...
Saccharomyces cerevisiae
Curr. Med. Chem.
11
807-826
2004
-
-
-
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-
-
1
-
-
-
-
3
-
3
-
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5
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1
1
-
-
-
750703
North
Sirtuins Sir2-related NAD-de ...
Archaeoglobus fulgidus, Saccharomyces cerevisiae, Homo sapiens, Archaeoglobus fulgidus ATCC 49558
Genome Biol.
5
224
2004
-
-
-
-
-
-
-
-
3
3
-
4
-
9
-
-
-
-
-
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-
5
-
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-
-
-
-
-
-
-
-
1
1
-
-
-
751318
Zhao
Structure and substrate bindi ...
Escherichia coli
J. Mol. Biol.
337
731-741
2004
-
-
1
1
-
-
-
-
-
1
-
-
-
6
-
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3
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-
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-
-
-
-
751547
Avalos
Structural basis for the mech ...
Archaeoglobus fulgidus
Mol. Cell
13
639-648
2004
-
-
1
1
-
-
-
-
-
-
-
1
-
1
-
-
1
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
749878
Sauve
Sir2 regulation by nicotinami ...
Archaeoglobus fulgidus, Saccharomyces cerevisiae, Mus musculus
Biochemistry
42
9249-9256
2003
-
-
-
-
-
-
15
9
-
-
-
12
-
3
-
-
-
-
-
-
-
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18
-
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-
-
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-
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3
-
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-
15
-
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12
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-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
751013
Jackson
Mechanism of nicotinamide inh ...
Saccharomyces cerevisiae, Homo sapiens
J. Biol. Chem.
278
50985-50998
2003
-
-
-
-
-
-
13
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
6
-
6
-
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-
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2
-
-
-
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-
2
-
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-
13
2
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2
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-
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-
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6
-
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-
-
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-
-
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-
-
-
-
-
752023
Parsons
Histone deacetylation by Sir2 ...
Drosophila melanogaster
Proc. Natl. Acad. Sci. USA
100
1609-1614
2003
-
-
1
-
-
-
1
-
-
-
-
1
-
3
-
-
1
-
-
-
-
-
11
1
3
-
-
-
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1
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1
1
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1
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-
-
11
1
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-
-
-
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1
1
-
-
-
729638
Langley
Human SIR2 deacetylates p53 an ...
Homo sapiens
EMBO J.
21
2383-2396
2002
-
-
-
-
-
-
-
-
2
-
-
1
-
7
-
-
-
-
-
-
-
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2
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1
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2
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-
-
-
-
-
-
-
-
-
-
730840
Onyango
SIRT3, a human SIR2 homologue, ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
99
13653-13658
2002
-
-
1
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2
-
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1
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4
-
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1
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-
-
-
-
-
-
-
-
752253
Starai
Sir2-dependent activation of ...
Salmonella enterica
Science
298
2390-2392
2002
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
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1
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-
-
-
-
-
-
-
-
-
-
729560
Vaziri
hSIR2(SIRT1) functions as an N ...
Homo sapiens
Cell
107
149-159
2001
-
-
-
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-
-
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-
1
-
1
-
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2
-
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-
-
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-
-
-
-
1
1
-
-
-
749874
Sauve
Chemistry of gene silencing ...
Thermotoga maritima
Biochemistry
40
15456-15463
2001
-
-
-
-
-
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-
-
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-
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1
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
750253
Min
Crystal structure of a SIR2 h ...
Archaeoglobus fulgidus
Cell
105
269-279
2001
-
-
1
1
4
-
1
-
-
1
-
1
-
1
-
-
1
-
-
-
-
-
2
-
2
-
-
-
-
-
-
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-
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1
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
752068
Landry
The silencing protein SIR2 an ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
97
5807-5811
2000
-
-
1
-
-
-
1
-
-
-
-
-
-
3
-
-
1
-
-
-
-
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-
4
-
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