Literature summary for 2.3.1.286 extracted from

Yu, W.; Dittenhafer-Reed, K.E.; Denu, J.M.
SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status (2012), J. Biol. Chem., 287, 14078-14086.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine413	Mus musculus	acetylation of Lys413 decreases catalysis and SIRT3 reactivates isocitrate dehydrogenase 2 upon deacetylation	nicotinamide + [isocitrate dehydrogenase 2]-L-lysine413 + 2'-O-acetyl-ADP-ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8R104	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine413	-	Mus musculus	nicotinamide + [isocitrate dehydrogenase 2]-L-lysine413 + 2'-O-acetyl-ADP-ribose	-	?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine413	acetylation of Lys413 decreases catalysis and SIRT3 reactivates isocitrate dehydrogenase 2 upon deacetylation	Mus musculus	nicotinamide + [isocitrate dehydrogenase 2]-L-lysine413 + 2'-O-acetyl-ADP-ribose	-	?

Synonyms

Synonyms	Comment	Organism
SIRT3	-	Mus musculus

General Information

General Information	Comment	Organism
metabolism	acetylation of Lys413 decreases catalysis and SIRT3 reactivates isocitrate dehydrogenase 2 upon deacetylation. SIRT3-dependent deacetylation of isocitrate dehydrogenase 2 suppresses cellular stress by reactive oxygen species (ROS). Acetylation of Lys413 is regulated by SIRT3 in response to calorie and glucose restriction	Mus musculus

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Release 2023.1 (January 2023)