Literature summary for 2.3.1.286 extracted from

Vaziri, H.; Dessain, S.K.; Ng Eaton, E.; Imai, S.I.; Frye, R.A.; Pandita, T.K.; Guarente, L.; Weinberg, R.A.
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase (2001), Cell, 107, 149-159.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [p53 protein]-N6-acetyl-L-lysine382	Homo sapiens	Sir2 is involved in the regulation of p53 function via deacetylation	nicotinamide + [p53 protein]-L-lysine382 + 2'-O-acetyl-ADP ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96EB6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [p53 protein]-N6-acetyl-L-lysine382	-	Homo sapiens	nicotinamide + [p53 protein]-L-lysine382 + 2'-O-acetyl-ADP ribose	-	?
NAD+ + [p53 protein]-N6-acetyl-L-lysine382	Sir2 is involved in the regulation of p53 function via deacetylation	Homo sapiens	nicotinamide + [p53 protein]-L-lysine382 + 2'-O-acetyl-ADP ribose	-	?

Synonyms

Synonyms	Comment	Organism
SIRT1	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	Sir2 is involved in the regulation of p53 function via deacetylation	Homo sapiens

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Release 2023.1 (January 2023)