Literature summary for 2.3.1.284 extracted from

Seeliger, J.C.; Holsclaw, C.M.; Schelle, M.W.; Botyanszki, Z.; Gilmore, S.A.; Tully, S.E.; Niederweis, M.; Cravatt, B.F.; Leary, J.A.; Bertozzi, C.R.
Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis (2012), J. Biol. Chem., 287, 7990-8000 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
tetrahydrolipstatin	lipase inhibitor tetrahydrolipstatin disrupts Chp1 activity	Mycobacterium tuberculosis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	membrane-associated	Mycobacterium tuberculosis	16020	-

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	O07801	-	-
Mycobacterium tuberculosis H37Rv	O07801	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-alpha,alpha-trehalose	-	Mycobacterium tuberculosis	3,6,6'-tris-(hydroxy)phthioceranyl-2-palmitoyl(stearoyl)-2'-sulfo-alpha-alpha-trehalose + 2 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose	-	?
3 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-alpha,alpha-trehalose	-	Mycobacterium tuberculosis H37Rv	3,6,6'-tris-(hydroxy)phthioceranyl-2-palmitoyl(stearoyl)-2'-sulfo-alpha-alpha-trehalose + 2 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose	-	?

Synonyms

Synonyms	Comment	Organism
rv3822	-	Mycobacterium tuberculosis
rv3822	gene locus name	Mycobacterium tuberculosis
SL1278 acyltransferase Chp1	-	Mycobacterium tuberculosis

General Information

General Information	Comment	Organism
physiological function	acyltransferase Chp1 accepts a diacyl sulfolipid and transfers an acyl group regioselectively from one donor substrate molecule to a second acceptor molecule in two successive reactions to yield a tetraacylated product. Chp1 is fully active in vitro, but in Mycobacterium tuberculosis, its function is potentiated by sulfolipid transporter MmpL8	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)