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Literature summary for 2.3.1.283 extracted from

  • Kumar, P.; Schelle, M.W.; Jain, M.; Lin, F.L.; Petzold, C.J.; Leavell, M.D.; Leary, J.A.; Cox, J.S.; Bertozzi, C.R.
    PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1 (2007), Proc. Natl. Acad. Sci. USA, 104, 11221-11226 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a (hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose Mycobacterium tuberculosis
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 a 3'-(hydroxy)phthioceranyl-2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose + holo-[(hydroxy)phthioceranic acid synthase]
-
 ?
a (hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose Mycobacterium tuberculosis H37Rv
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 a 3'-(hydroxy)phthioceranyl-2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose + holo-[(hydroxy)phthioceranic acid synthase]
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WIK9
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-
Mycobacterium tuberculosis H37Rv P9WIK9
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a (hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose
-
 Mycobacterium tuberculosis a 3'-(hydroxy)phthioceranyl-2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose + holo-[(hydroxy)phthioceranic acid synthase]
-
 ?
a (hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose
-
 Mycobacterium tuberculosis H37Rv a 3'-(hydroxy)phthioceranyl-2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose + holo-[(hydroxy)phthioceranic acid synthase]
-
 ?

General Information

General Information Comment Organism
physiological function acyltransferases PapA2 and PapA1 are responsible for the sequential acylation of trehalose-2-sulfate to form diacylated intermediate sulfolipid SL1278 and are essential for sulfolipid-1 biosynthesis. In vitro, recombinant PapA2 converts of trehalose-2-sulfate to 2'-palmitoyl of trehalose-2-sulfate , and PapA1 further elaborates this SL-sulfolipid-1 intermediate to an analog of SL1278. PapA2 and PapA1 play an essential role in sulfolipid-1 biosynthesis . The loss of sulfolipid-1 (and SL1278) in Papa1 and Papa2 deletion mutants does not appear to affect bacterial replication or trafficking Mycobacterium tuberculosis