Protein Variants | Comment | Organism |
---|---|---|
D128A | mutation in HHx3DGx13Y motif, loss of activity | Mycobacterium tuberculosis |
H123A | about 1.7- to 2.3fold decrease in ester formation | Mycobacterium tuberculosis |
H124A | mutation in HHx3DGx13Y motif, loss of activity | Mycobacterium tuberculosis |
Y143F | about 1.9fold decrease in ester formation | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
octan-1-ol | substrate inhibition | Mycobacterium tuberculosis | |
palmitoyl-CoA | substrate inhibition | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.004 | - |
palmitoyl-CoA | pH 6.5, 387°C | Mycobacterium tuberculosis | |
0.5 | - |
octan-1-ol | pH 6.5, 387°C | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WIN5 | - |
- |
Mycobacterium tuberculosis ATCC 25618 | P9WIN5 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-octan-2-ol + palmitoyl-CoA | - |
Mycobacterium tuberculosis | (R)-2-octanyl palmitate + CoA | - |
? | |
(R)-octan-2-ol + palmitoyl-CoA | - |
Mycobacterium tuberculosis ATCC 25618 | (R)-2-octanyl palmitate + CoA | - |
? | |
(R,S)-octan-2-ol + palmitoyl-CoA | - |
Mycobacterium tuberculosis | (R,S)-2-octanyl palmitate + CoA | - |
? | |
(R,S)-octan-2-ol + palmitoyl-CoA | - |
Mycobacterium tuberculosis ATCC 25618 | (R,S)-2-octanyl palmitate + CoA | - |
? | |
decan-1-ol + palmitoyl-CoA | - |
Mycobacterium tuberculosis | 1-decyl palmitate + CoA | - |
? | |
decan-1-ol + palmitoyl-CoA | - |
Mycobacterium tuberculosis ATCC 25618 | 1-decyl palmitate + CoA | - |
? | |
hexadecanol + palmitoyl-CoA | - |
Mycobacterium tuberculosis | hexadecyl palmitate + CoA | - |
? | |
hexadecanol + palmitoyl-CoA | - |
Mycobacterium tuberculosis ATCC 25618 | hexadecyl palmitate + CoA | - |
? | |
additional information | enzyme shows a preference for saturated medium chain alcohols, with 1-octanol displaying the highest ester formation stoichiometry. 20- and 5fold more ester is formed with (R)-(-)2-octanol and (S)-(-)1,2-decanediol, respectively, than with their corresponding enantiomers | Mycobacterium tuberculosis | ? | - |
? | |
additional information | enzyme shows a preference for saturated medium chain alcohols, with 1-octanol displaying the highest ester formation stoichiometry. 20- and 5fold more ester is formed with (R)-(-)2-octanol and (S)-(-)1,2-decanediol, respectively, than with their corresponding enantiomers | Mycobacterium tuberculosis ATCC 25618 | ? | - |
? | |
nonan-1-ol + palmitoyl-CoA | - |
Mycobacterium tuberculosis | 1-nonyl palmitate + CoA | - |
? | |
octan-1-ol + elaidoyl-CoA | - |
Mycobacterium tuberculosis | 1-octyl elaidoate + CoA | - |
? | |
octan-1-ol + heptadecanoyl-CoA | - |
Mycobacterium tuberculosis | 1-octyl heptadecanoate + CoA | - |
? | |
octan-1-ol + lauroyl-CoA | - |
Mycobacterium tuberculosis | 1-octyl laurate + CoA | - |
? | |
octan-1-ol + oleoyl-CoA | - |
Mycobacterium tuberculosis | 1-octyl oleate + CoA | - |
? | |
octan-1-ol + palmitoyl-CoA | - |
Mycobacterium tuberculosis | 1-octyl palmitate + CoA | - |
? | |
octan-1-ol + stearoyl-CoA | - |
Mycobacterium tuberculosis | 1-octyl stearate + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
papA5 | - |
Mycobacterium tuberculosis |
polyketide-associated protein A5 | - |
Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0004 | - |
octan-1-ol | pH 6.5, 387°C | Mycobacterium tuberculosis | |
0.00045 | - |
palmitoyl-CoA | pH 6.5, 387°C | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
- |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0096 | - |
palmitoyl-CoA | pH 6.5, 37°C | Mycobacterium tuberculosis | |
3 | - |
octan-1-ol | pH 6.5, 37°C | Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | PapA5 catalyzes diesterification of phthiocerol and phthiodiolone with mycocerosate. Presence of PapA5 is required for synthesis of phthiocerol and phthiodiolone dimycocerosate esters | Mycobacterium tuberculosis |