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Literature summary for 2.3.1.282 extracted from

  • Chavadi, S.S.; Onwueme, K.C.; Edupuganti, U.R.; Jerome, J.; Chatterjee, D.; Soll, C.E.; Quadri, L.E.
    The mycobacterial acyltransferase PapA5 is required for biosynthesis of cell wall-associated phenolic glycolipids (2012), Microbiology, 158, 1379-1387 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.282

Inhibitors

Inhibitors Comment Organism Structure
glycosyl-phenolphthiocerol substrate inhibition Mycobacterium marinum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.103
-
 glycosyl-phenolphthiocerol pH 6.2, 37°C Mycobacterium marinum

Organism

Organism UniProt Comment Textmining
Mycobacterium marinum B2HIM3
-
-
Mycobacterium marinum ATCC BAA-535 B2HIM3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 palmitoyl-CoA + glycosyl-phenolphthiocerol substrate isolated from Mycobacterium leprae in infected Armadillo tissue Mycobacterium marinum dipalmitoyl glycosyl-phenolphthiocerol + 2 CoA
-
 ?
2 palmitoyl-CoA + glycosyl-phenolphthiocerol substrate isolated from Mycobacterium leprae in infected Armadillo tissue Mycobacterium marinum ATCC BAA-535 dipalmitoyl glycosyl-phenolphthiocerol + 2 CoA
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.496
-
 glycosyl-phenolphthiocerol pH 6.2, 37°C Mycobacterium marinum

General Information

General Information Comment Organism
physiological function PapA5 is essential for production of phenolic glycolipids. PapA5 catalyses the acylation of diol-containing polyketides to form of phenolic glycolipids Mycobacterium marinum