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Literature summary for 2.3.1.28 extracted from

  • Ghafoori, S.M.; Robles, A.M.; Arada, A.M.; Shirmast, P.; Dranow, D.M.; Mayclin, S.J.; Lorimer, D.D.; Myler, P.J.; Edwards, T.E.; Kuhn, M.L.; Forwood, J.K.
    Structural characterization of a Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1 (2021), Sci. Rep., 11, 9453.
    View publication on PubMed
Search for more literature for 2.3.1.28

Application

Application Comment Organism
molecular biology chloramphenicol acetyltransferases play important roles in antibiotic resistance and can be transferred in genetic mobile elements Elizabethkingia anophelis

Cloned(Commentary)

Cloned (Comment) Organism
sitting drop vapor diffusion method Elizabethkingia anophelis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + chloramphenicol Elizabethkingia anophelis
-
 CoA + chloramphenicol 3-acetate
-
 ?
acetyl-CoA + chloramphenicol Elizabethkingia anophelis NUHP1
-
 CoA + chloramphenicol 3-acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Elizabethkingia anophelis A0A077EJ45
-
-
Elizabethkingia anophelis NUHP1 A0A077EJ45
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Elizabethkingia anophelis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + chloramphenicol
-
 Elizabethkingia anophelis CoA + chloramphenicol 3-acetate
-
 ?
acetyl-CoA + chloramphenicol
-
 Elizabethkingia anophelis NUHP1 CoA + chloramphenicol 3-acetate
-
 ?

Synonyms

Synonyms Comment Organism
CAT
-
 Elizabethkingia anophelis
chloramphenicol acetyltransferase
-
 Elizabethkingia anophelis

General Information

General Information Comment Organism
additional information the enzyme catalyses the acetylation of the antibiotic chloramphenicol, thereby reducing its effectiveness as a viable drug for therapy Elizabethkingia anophelis
physiological function chloramphenicol acetyltransferase plays important roles in antibiotic resistance Elizabethkingia anophelis