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Literature summary for 2.3.1.28 extracted from

  • Liao, J.; Qi, Q.; Kuang, L.; Zhou, Y.; Xiao, Q.; Liu, T.; Wang, X.; Guo, L.; Jiang, Y.
    Chloramphenicol binding sites of Acinetobacter baumannii chloramphenicol acetyltransferase CatB8 (2024), ACS Infect. Dis., 10, 870-878.
    View publication on PubMed
Search for more literature for 2.3.1.28

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21(DE3) Acinetobacter baumannii

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor-diffusion method at 18°C, high-resolution cocrystal structure of CatB8 with chloramphenicol Acinetobacter baumannii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + chloramphenicol Acinetobacter baumannii
-
 CoA + chloramphenicol 3-acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii Q6Q627
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Acinetobacter baumannii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + chloramphenicol
-
 Acinetobacter baumannii CoA + chloramphenicol 3-acetate
-
 ?
acetyl-CoA + chloramphenicol chloramphenicol is recruited through the key residues D41, Q77, and E94. chloramphenicol and acetyl-CoA enter the catalytic pocket of CatB8, where an acetylation reaction takes place Acinetobacter baumannii CoA + chloramphenicol 3-acetate
-
 ?

Synonyms

Synonyms Comment Organism
catB8
-
 Acinetobacter baumannii